Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy

Yanchun Wei, Sen Liu, Changjiang Pan, Zhongmei Yang, Ying Liu, Jianfang Yong, Li Quan Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an, Jiangsu, People’s Republic of ChinaCorrespondence:...

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Autores principales:	Wei Y, Liu S, Pan C, Yang Z, Liu Y, Yong J, Quan L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	temperature photothermal therapy molecule antennas upconversion nanoparticle Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5215889301f14990a61173af58bb54bb
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spelling	oai:doaj.org-article:5215889301f14990a61173af58bb54bb2021-12-02T06:40:47ZMolecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy1178-2013https://doaj.org/article/5215889301f14990a61173af58bb54bb2020-03-01T00:00:00Zhttps://www.dovepress.com/molecular-antenna-sensitized-upconversion-nanoparticle-for-temperature-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yanchun Wei, Sen Liu, Changjiang Pan, Zhongmei Yang, Ying Liu, Jianfang Yong, Li Quan Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an, Jiangsu, People’s Republic of ChinaCorrespondence: Yanchun Wei; Li QuanJiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an, Jiangsu, People’s Republic of ChinaTel +86-137 1691 3791Email weiyanchunha@hyit.edu.cn; quanli2016@hyit.edu.cnBackground: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy.Materials and Methods: NaYF4:Yb3+,Er3+,Nd3+, PL-PEG-NH2, IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion.Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed.Conclusion: Precision photothermal therapy can thus be achieved by highly efficient near-infrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.Keywords: temperature, photothermal therapy, molecule antennas, upconversion nanoparticleWei YLiu SPan CYang ZLiu YYong JQuan LDove Medical Pressarticletemperaturephotothermal therapymolecule antennasupconversion nanoparticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 1409-1420 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	temperature photothermal therapy molecule antennas upconversion nanoparticle Medicine (General) R5-920
spellingShingle	temperature photothermal therapy molecule antennas upconversion nanoparticle Medicine (General) R5-920 Wei Y Liu S Pan C Yang Z Liu Y Yong J Quan L Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
description	Yanchun Wei, Sen Liu, Changjiang Pan, Zhongmei Yang, Ying Liu, Jianfang Yong, Li Quan Jiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an, Jiangsu, People’s Republic of ChinaCorrespondence: Yanchun Wei; Li QuanJiangsu Provincial Engineering Research Center for Biomedical Materials and Advanced Medical Devices, Huaiyin Institute of Technology, Huai’an, Jiangsu, People’s Republic of ChinaTel +86-137 1691 3791Email weiyanchunha@hyit.edu.cn; quanli2016@hyit.edu.cnBackground: Photothermal therapy with accurate and real-time temperature detection is desired in clinic. Upconversion nanocrystals (UCNs) are candidate materials for simultaneous temperature detection and photothermal agents carrying. However, the weak luminescence and multiple laser excitations of UCNs limit their application in thermal therapy.Materials and Methods: NaYF4:Yb3+,Er3+,Nd3+, PL-PEG-NH2, IR-806 and folic acid are selected as structural components. A nanoprobe (NP) integrated with efficient photothermal conversion and sensitive temperature detection capabilities is synthesized for precise photothermal therapy. The probes are based on near-infrared upconversion nanocrystals doped with Yb, Er and Nd ions, which can be excited by 808 nm light. IR-806 dye molecules are modified on the surface as molecular antennas to strongly absorb near-infrared photons for energy transfer and conversion.Results: The results show that under an 808 nm laser irradiation upconversion luminescence of the nanocrystals is enhanced based on both the Nd ion absorption and the FRET energy transfer of IR-806. The luminescence ratio at 520 and 545 nm is calculated to accurately monitor the temperature of the nanoparticles. The temperature of the nanoprobes increases significantly through energy conversion of the molecular antennas. The nanoparticles are found successfully distributed to tumor cells and tumor tissue due to the modification of the biocompatible molecules on the surface. Tumor cells can be killed efficiently based on the photothermal effect of the NPs. Under the laser irradiation, temperature at mouse tumor site increases significantly, tissue necrosis and tumor cell death can be observed.Conclusion: Precision photothermal therapy can thus be achieved by highly efficient near-infrared light absorption and accurate temperature monitoring, making it promising for tumor treatment, as well as the biological microzone temperature detection.Keywords: temperature, photothermal therapy, molecule antennas, upconversion nanoparticle
format	article
author	Wei Y Liu S Pan C Yang Z Liu Y Yong J Quan L
author_facet	Wei Y Liu S Pan C Yang Z Liu Y Yong J Quan L
author_sort	Wei Y
title	Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
title_short	Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
title_full	Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
title_fullStr	Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
title_full_unstemmed	Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy
title_sort	molecular antenna-sensitized upconversion nanoparticle for temperature monitored precision photothermal therapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5215889301f14990a61173af58bb54bb
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_version_	1718399753248571392

Molecular Antenna-Sensitized Upconversion Nanoparticle for Temperature Monitored Precision Photothermal Therapy

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