The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study.
<h4>Purpose</h4>Metastatic neuroendocrine tumors secrete serotonin and other vasoactive substances that are responsible for carcinoid syndrome and carcinoid heart disease. We sought to evaluate the discriminatory utility of diagnostic biomarkers in determining the presence and severity o...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/5217811fa4b24bbab6c22b18b2408990 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:5217811fa4b24bbab6c22b18b2408990 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:5217811fa4b24bbab6c22b18b24089902021-11-18T08:55:33ZThe association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study.1932-620310.1371/journal.pone.0073679https://doaj.org/article/5217811fa4b24bbab6c22b18b24089902013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24069222/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>Metastatic neuroendocrine tumors secrete serotonin and other vasoactive substances that are responsible for carcinoid syndrome and carcinoid heart disease. We sought to evaluate the discriminatory utility of diagnostic biomarkers in determining the presence and severity of carcinoid heart disease in patients with metastatic neuroendocrine tumors.<h4>Patients and methods</h4>A cross-sectional study of patients with neuroendocrine tumors with documented liver metastases and/or carcinoid syndrome between April 2009-October 2012 in 5 tertiary referral centers. Serum was analyzed for Chromogranin A, Chromogranin B and N-terminal pro Brain Natriuretic Peptide (NT-proBNP). Plasma was analyzed for Neurokinin A and 5-Hydroxyindoleacetic acid (5HIAA). Echocardiography was used to determine the presence and severity of carcinoid heart disease. Non-parametric receiver operating characteristic curves were constructed for biomarkers, and the area under the curve determined. The severity of cardiac involvement was correlated with the concentration of each biomarker.<h4>Results</h4>A total of 187 patients were identified of whom 37 (20%) had carcinoid heart disease. Significantly higher median values of all biomarkers were found in the patients with cardiac involvement. NT-proBNP and plasma 5HIAA had the highest areas under the curve for the prediction of carcinoid heart disease [NT-proBNP 0.82 (95% confidence interval 0.74-0.90, p<0.0001) and 5HIAA 0.85 (95% confidence interval 0.78-0.92, p<0.0001]. NT-proBNP was moderately correlated (r = 0.48, p<0.001) whereas plasma 5HIAA was only weakly correlated (r = 0.34, p<0.001) with the echocardiographic severity score.<h4>Conclusion</h4>NT-proBNP and plasma 5HIAA are both sensitive and specific biomarkers for the presence of carcinoid heart disease whereas only NT-proBNP is moderately correlated with disease severity.Rebecca DobsonMalcolm I BurgessMelissa BanksD Mark PritchardJiten VoraJuan W ValleChristopher WongCarrie ChadwickKeith GeorgeBrian KeevilJoanne AdawayJoy E S ArdillAlan AnthoneyUschi HofmannGraeme J PostonDaniel J CuthbertsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73679 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Rebecca Dobson Malcolm I Burgess Melissa Banks D Mark Pritchard Jiten Vora Juan W Valle Christopher Wong Carrie Chadwick Keith George Brian Keevil Joanne Adaway Joy E S Ardill Alan Anthoney Uschi Hofmann Graeme J Poston Daniel J Cuthbertson The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| description |
<h4>Purpose</h4>Metastatic neuroendocrine tumors secrete serotonin and other vasoactive substances that are responsible for carcinoid syndrome and carcinoid heart disease. We sought to evaluate the discriminatory utility of diagnostic biomarkers in determining the presence and severity of carcinoid heart disease in patients with metastatic neuroendocrine tumors.<h4>Patients and methods</h4>A cross-sectional study of patients with neuroendocrine tumors with documented liver metastases and/or carcinoid syndrome between April 2009-October 2012 in 5 tertiary referral centers. Serum was analyzed for Chromogranin A, Chromogranin B and N-terminal pro Brain Natriuretic Peptide (NT-proBNP). Plasma was analyzed for Neurokinin A and 5-Hydroxyindoleacetic acid (5HIAA). Echocardiography was used to determine the presence and severity of carcinoid heart disease. Non-parametric receiver operating characteristic curves were constructed for biomarkers, and the area under the curve determined. The severity of cardiac involvement was correlated with the concentration of each biomarker.<h4>Results</h4>A total of 187 patients were identified of whom 37 (20%) had carcinoid heart disease. Significantly higher median values of all biomarkers were found in the patients with cardiac involvement. NT-proBNP and plasma 5HIAA had the highest areas under the curve for the prediction of carcinoid heart disease [NT-proBNP 0.82 (95% confidence interval 0.74-0.90, p<0.0001) and 5HIAA 0.85 (95% confidence interval 0.78-0.92, p<0.0001]. NT-proBNP was moderately correlated (r = 0.48, p<0.001) whereas plasma 5HIAA was only weakly correlated (r = 0.34, p<0.001) with the echocardiographic severity score.<h4>Conclusion</h4>NT-proBNP and plasma 5HIAA are both sensitive and specific biomarkers for the presence of carcinoid heart disease whereas only NT-proBNP is moderately correlated with disease severity. |
| format |
article |
| author |
Rebecca Dobson Malcolm I Burgess Melissa Banks D Mark Pritchard Jiten Vora Juan W Valle Christopher Wong Carrie Chadwick Keith George Brian Keevil Joanne Adaway Joy E S Ardill Alan Anthoney Uschi Hofmann Graeme J Poston Daniel J Cuthbertson |
| author_facet |
Rebecca Dobson Malcolm I Burgess Melissa Banks D Mark Pritchard Jiten Vora Juan W Valle Christopher Wong Carrie Chadwick Keith George Brian Keevil Joanne Adaway Joy E S Ardill Alan Anthoney Uschi Hofmann Graeme J Poston Daniel J Cuthbertson |
| author_sort |
Rebecca Dobson |
| title |
The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| title_short |
The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| title_full |
The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| title_fullStr |
The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| title_full_unstemmed |
The association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| title_sort |
association of a panel of biomarkers with the presence and severity of carcinoid heart disease: a cross-sectional study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/5217811fa4b24bbab6c22b18b2408990 |
| work_keys_str_mv |
AT rebeccadobson theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT malcolmiburgess theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT melissabanks theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT dmarkpritchard theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT jitenvora theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT juanwvalle theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT christopherwong theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT carriechadwick theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT keithgeorge theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT briankeevil theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT joanneadaway theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT joyesardill theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT alananthoney theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT uschihofmann theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT graemejposton theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT danieljcuthbertson theassociationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT rebeccadobson associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT malcolmiburgess associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT melissabanks associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT dmarkpritchard associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT jitenvora associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT juanwvalle associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT christopherwong associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT carriechadwick associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT keithgeorge associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT briankeevil associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT joanneadaway associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT joyesardill associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT alananthoney associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT uschihofmann associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT graemejposton associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy AT danieljcuthbertson associationofapanelofbiomarkerswiththepresenceandseverityofcarcinoidheartdiseaseacrosssectionalstudy |
| _version_ |
1718421140543635456 |