Alterations of oral microbiota in patients with panic disorder

The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship be...

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Autores principales:	Zunli Xie, Weiqing Jiang, Mingzhu Deng, Wei Wang, Xian Xie, Xia Feng, Yinping Shi, Xueyan Zhang, Dong Song, Ziyu Yuan, Yonggang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	anxiety disorder panic disorder oral microbiota 16s rrna sequencing function prediction Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/521bb0a74e844e27951a14a82055d80d
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spelling	oai:doaj.org-article:521bb0a74e844e27951a14a82055d80d2021-11-04T15:51:54ZAlterations of oral microbiota in patients with panic disorder2165-59792165-598710.1080/21655979.2021.1994738https://doaj.org/article/521bb0a74e844e27951a14a82055d80d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.1994738https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the oral microbiota of patients with PD (n = 26) and healthy controls (n = 40). Patients with PD exhibited higher alpha diversity (abundance and evenness) in their oral microbiota than healthy controls, while analysis of beta diversity revealed that the two groups differed in microbial community composition. Moreover, the relative abundance of 61 genera differed between them. Overall, PD resulted in distinct oral microbial profiles that could be potential diagnostic markers and therapeutic targets.Zunli XieWeiqing JiangMingzhu DengWei WangXian XieXia FengYinping ShiXueyan ZhangDong SongZiyu YuanYonggang WangTaylor & Francis Grouparticleanxiety disorderpanic disorderoral microbiota16s rrna sequencingfunction predictionBiotechnologyTP248.13-248.65ENBioengineered, Vol 12, Iss 1, Pp 9103-9112 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anxiety disorder panic disorder oral microbiota 16s rrna sequencing function prediction Biotechnology TP248.13-248.65
spellingShingle	anxiety disorder panic disorder oral microbiota 16s rrna sequencing function prediction Biotechnology TP248.13-248.65 Zunli Xie Weiqing Jiang Mingzhu Deng Wei Wang Xian Xie Xia Feng Yinping Shi Xueyan Zhang Dong Song Ziyu Yuan Yonggang Wang Alterations of oral microbiota in patients with panic disorder
description	The main characteristics of panic disorder (PD) include recurrent panic attacks and persistent worry, accompanied by other physical and cognitive symptoms. While recent studies have revealed that gut bacteria play an important role in anxiety and depression, little is known about the relationship between oral microbiota and PD. Therefore, the objective of this study was to explore a possible correlation between oral microbiota and PD. We conducted 16S rRNA sequencing to compare differences in the oral microbiota of patients with PD (n = 26) and healthy controls (n = 40). Patients with PD exhibited higher alpha diversity (abundance and evenness) in their oral microbiota than healthy controls, while analysis of beta diversity revealed that the two groups differed in microbial community composition. Moreover, the relative abundance of 61 genera differed between them. Overall, PD resulted in distinct oral microbial profiles that could be potential diagnostic markers and therapeutic targets.
format	article
author	Zunli Xie Weiqing Jiang Mingzhu Deng Wei Wang Xian Xie Xia Feng Yinping Shi Xueyan Zhang Dong Song Ziyu Yuan Yonggang Wang
author_facet	Zunli Xie Weiqing Jiang Mingzhu Deng Wei Wang Xian Xie Xia Feng Yinping Shi Xueyan Zhang Dong Song Ziyu Yuan Yonggang Wang
author_sort	Zunli Xie
title	Alterations of oral microbiota in patients with panic disorder
title_short	Alterations of oral microbiota in patients with panic disorder
title_full	Alterations of oral microbiota in patients with panic disorder
title_fullStr	Alterations of oral microbiota in patients with panic disorder
title_full_unstemmed	Alterations of oral microbiota in patients with panic disorder
title_sort	alterations of oral microbiota in patients with panic disorder
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/521bb0a74e844e27951a14a82055d80d
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_version_	1718444713917284352

Alterations of oral microbiota in patients with panic disorder

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