New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy

Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsack...

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Autor principal: Lundstrom K
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:521c536d77ef43ef940735d343d5d01b2021-12-02T00:53:26ZNew frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy1177-5491https://doaj.org/article/521c536d77ef43ef940735d343d5d01b2018-02-01T00:00:00Zhttps://www.dovepress.com/new-frontiers-in-oncolytic-viruses-optimizing-and-selecting-for-virus--peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsackie viruses, and vaccinia viruses – have been applied as either naturally occurring or engineered vectors. Numerous studies in animal-tumor models have demonstrated substantial tumor regression and prolonged survival rates. Moreover, clinical trials have confirmed good safety profiles and therapeutic efficacy for oncolytic viruses. Most encouragingly, the first cancer gene-therapy drug – Gendicine, based on oncolytic adenovirus type 5 – was approved in China. Likewise, a second-generation oncolytic herpes simplex virus-based drug for the treatment of melanoma has been registered in the US and Europe as talimogene laherparepvec. Keywords: immunotherapy, viral vectors, clinical trials, drug approvalLundstrom KDove Medical Pressarticleimmunotherapyviral vectorsclinical trialsdrug approvalMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 12, Pp 43-60 (2018)
institution DOAJ
collection DOAJ
language EN
topic immunotherapy
viral vectors
clinical trials
drug approval
Medicine (General)
R5-920
spellingShingle immunotherapy
viral vectors
clinical trials
drug approval
Medicine (General)
R5-920
Lundstrom K
New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
description Kenneth Lundstrom PanTherapeutics, Lutry, Switzerland Abstract: Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses – adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsackie viruses, and vaccinia viruses – have been applied as either naturally occurring or engineered vectors. Numerous studies in animal-tumor models have demonstrated substantial tumor regression and prolonged survival rates. Moreover, clinical trials have confirmed good safety profiles and therapeutic efficacy for oncolytic viruses. Most encouragingly, the first cancer gene-therapy drug – Gendicine, based on oncolytic adenovirus type 5 – was approved in China. Likewise, a second-generation oncolytic herpes simplex virus-based drug for the treatment of melanoma has been registered in the US and Europe as talimogene laherparepvec. Keywords: immunotherapy, viral vectors, clinical trials, drug approval
format article
author Lundstrom K
author_facet Lundstrom K
author_sort Lundstrom K
title New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
title_short New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
title_full New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
title_fullStr New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
title_full_unstemmed New frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
title_sort new frontiers in oncolytic viruses: optimizing and selecting for virus strains with improved efficacy
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/521c536d77ef43ef940735d343d5d01b
work_keys_str_mv AT lundstromk newfrontiersinoncolyticvirusesoptimizingandselectingforvirusstrainswithimprovedefficacy
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