Metastable hybridization-based DNA information storage to allow rapid and permanent erasure

The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing da...

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Main Authors:	Jangwon Kim, Jin H. Bae, Michael Baym, David Yu Zhang
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/521caa4ca79b45d38fd209aba923c447
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spelling	oai:doaj.org-article:521caa4ca79b45d38fd209aba923c4472021-12-02T19:16:29ZMetastable hybridization-based DNA information storage to allow rapid and permanent erasure10.1038/s41467-020-18842-62041-1723https://doaj.org/article/521caa4ca79b45d38fd209aba923c4472020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18842-6https://doaj.org/toc/2041-1723The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing data recovery.Jangwon KimJin H. BaeMichael BaymDavid Yu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
description	The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing data recovery.
format	article
author	Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang
author_facet	Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang
author_sort	Jangwon Kim
title	Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
title_short	Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
title_full	Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
title_fullStr	Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
title_full_unstemmed	Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
title_sort	metastable hybridization-based dna information storage to allow rapid and permanent erasure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/521caa4ca79b45d38fd209aba923c447
work_keys_str_mv	AT jangwonkim metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT jinhbae metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT michaelbaym metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT davidyuzhang metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure
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Metastable hybridization-based DNA information storage to allow rapid and permanent erasure

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