Metastable hybridization-based DNA information storage to allow rapid and permanent erasure
The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing da...
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Nature Portfolio
2020
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oai:doaj.org-article:521caa4ca79b45d38fd209aba923c4472021-12-02T19:16:29ZMetastable hybridization-based DNA information storage to allow rapid and permanent erasure10.1038/s41467-020-18842-62041-1723https://doaj.org/article/521caa4ca79b45d38fd209aba923c4472020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18842-6https://doaj.org/toc/2041-1723The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing data recovery.Jangwon KimJin H. BaeMichael BaymDavid Yu ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020) |
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Science Q Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
description |
The chemical stability of DNA makes complete erasure of DNA-encoded data difficult. Here the authors mix true and false messages, differentiated by whether a truth marker oligo is bound to it, and show that brief exposure to elevated temperatures randomizes the binding of truth markers preventing data recovery. |
format |
article |
author |
Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang |
author_facet |
Jangwon Kim Jin H. Bae Michael Baym David Yu Zhang |
author_sort |
Jangwon Kim |
title |
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
title_short |
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
title_full |
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
title_fullStr |
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
title_full_unstemmed |
Metastable hybridization-based DNA information storage to allow rapid and permanent erasure |
title_sort |
metastable hybridization-based dna information storage to allow rapid and permanent erasure |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/521caa4ca79b45d38fd209aba923c447 |
work_keys_str_mv |
AT jangwonkim metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT jinhbae metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT michaelbaym metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure AT davidyuzhang metastablehybridizationbaseddnainformationstoragetoallowrapidandpermanenterasure |
_version_ |
1718376911385657344 |