IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN

The study deals with evaluation of immune parameters in healthy fertile women (n = 48) versus female patients with infertility of unknown origin (n = 386). A comparative analysis has shown similar patterns of immune dysfunction in women with primary infertility (n = 179) and recurrent spontaneous ab...

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Autores principales:	N. A. Khonina, M. A. Tikhonova, I. B. Dzutzeva, N. M. Pasman, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	infertility blocking antibodies cytokines nk-cells t-cells regulatory Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/521da88327f4467386e484297f061d3e
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spelling	oai:doaj.org-article:521da88327f4467386e484297f061d3e2021-11-18T08:03:41ZIMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN1563-06252313-741X10.15789/1563-0625-2010-6-511-520https://doaj.org/article/521da88327f4467386e484297f061d3e2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/444https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study deals with evaluation of immune parameters in healthy fertile women (n = 48) versus female patients with infertility of unknown origin (n = 386). A comparative analysis has shown similar patterns of immune dysfunction in women with primary infertility (n = 179) and recurrent spontaneous abortion (n = 207). The most common markers of immune dysfunction include decreased production of blocking antibodies (86.5% of cases), low proliferative response to paternal alloantigens in mixed leukocyte reaction (MLR) shown in 51.5% of cases, and increased number of activated CD56+CD16+NK-cells (42.0%). Decreased production of MLR-blocking antibodies may be caused by low lymphocyte response, due to the partner's HLA-similarity, or by predominance of Th1/proinflammatory cytokines and low contents of circulating regulatory CD4+CD25+T-cells. The study results demonstrate that development of primary infertility and recurrent spontaneous abortions is associated with a uniform set of immune disorders, thus probably reflecting a failure of suppressor rearrangement within immune system during periovulatory period of menstrual cycle.N. A. KhoninaM. A. TikhonovaI. B. DzutzevaN. M. PasmanA. A. OstaninE. R. ChernykhSPb RAACIarticleinfertilityblocking antibodiescytokinesnk-cellst-cells regulatoryImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 511-520 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	infertility blocking antibodies cytokines nk-cells t-cells regulatory Immunologic diseases. Allergy RC581-607
spellingShingle	infertility blocking antibodies cytokines nk-cells t-cells regulatory Immunologic diseases. Allergy RC581-607 N. A. Khonina M. A. Tikhonova I. B. Dzutzeva N. M. Pasman A. A. Ostanin E. R. Chernykh IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
description	The study deals with evaluation of immune parameters in healthy fertile women (n = 48) versus female patients with infertility of unknown origin (n = 386). A comparative analysis has shown similar patterns of immune dysfunction in women with primary infertility (n = 179) and recurrent spontaneous abortion (n = 207). The most common markers of immune dysfunction include decreased production of blocking antibodies (86.5% of cases), low proliferative response to paternal alloantigens in mixed leukocyte reaction (MLR) shown in 51.5% of cases, and increased number of activated CD56+CD16+NK-cells (42.0%). Decreased production of MLR-blocking antibodies may be caused by low lymphocyte response, due to the partner's HLA-similarity, or by predominance of Th1/proinflammatory cytokines and low contents of circulating regulatory CD4+CD25+T-cells. The study results demonstrate that development of primary infertility and recurrent spontaneous abortions is associated with a uniform set of immune disorders, thus probably reflecting a failure of suppressor rearrangement within immune system during periovulatory period of menstrual cycle.
format	article
author	N. A. Khonina M. A. Tikhonova I. B. Dzutzeva N. M. Pasman A. A. Ostanin E. R. Chernykh
author_facet	N. A. Khonina M. A. Tikhonova I. B. Dzutzeva N. M. Pasman A. A. Ostanin E. R. Chernykh
author_sort	N. A. Khonina
title	IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
title_short	IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
title_full	IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
title_fullStr	IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
title_full_unstemmed	IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN
title_sort	immune dysfunctions in women with infertility of unknown origin
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/521da88327f4467386e484297f061d3e
work_keys_str_mv	AT nakhonina immunedysfunctionsinwomenwithinfertilityofunknownorigin AT matikhonova immunedysfunctionsinwomenwithinfertilityofunknownorigin AT ibdzutzeva immunedysfunctionsinwomenwithinfertilityofunknownorigin AT nmpasman immunedysfunctionsinwomenwithinfertilityofunknownorigin AT aaostanin immunedysfunctionsinwomenwithinfertilityofunknownorigin AT erchernykh immunedysfunctionsinwomenwithinfertilityofunknownorigin
_version_	1718422476870909952

IMMUNE DYSFUNCTIONS IN WOMEN WITH INFERTILITY OF UNKNOWN ORIGIN

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