The neurotoxicity induced by engineered nanomaterials

Dan Ge,1,2,* Qiqi Du,1,2,* Bingqing Ran,1,2 Xingyu Liu,1,2 Xin Wang,1,2 Xuehu Ma,1 Fang Cheng,1,3 Bingbing Sun1,21State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 2Department of Chemical Engineering, Dalian University of Te...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ge D, Du Q, Ran B, Liu X, Wang X, Ma X, Cheng F, Sun B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Engineered Nanomaterials Neurotoxicity Oxidative Stress Inflammation DNA Damage Cell Death Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5225735374e741df93641aac78e22da2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5225735374e741df93641aac78e22da2
record_format	dspace
spelling	oai:doaj.org-article:5225735374e741df93641aac78e22da22021-12-02T02:10:49ZThe neurotoxicity induced by engineered nanomaterials1178-2013https://doaj.org/article/5225735374e741df93641aac78e22da22019-06-01T00:00:00Zhttps://www.dovepress.com/the-neurotoxicity-induced-by-engineered-nanomaterials-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Dan Ge,1,2,* Qiqi Du,1,2,* Bingqing Ran,1,2 Xingyu Liu,1,2 Xin Wang,1,2 Xuehu Ma,1 Fang Cheng,1,3 Bingbing Sun1,21State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 2Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3Department of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, People’s Republic of China*These authors contributed equally to this work Abstract: Engineered nanomaterials (ENMs) have been widely used in various fields due to their novel physicochemical properties. However, the use of ENMs has led to an increased exposure in humans, and the safety of ENMs has attracted much attention. It is universally acknowledged that ENMs could enter the human body via different routes, eg, inhalation, skin contact, and intravenous injection. Studies have proven that ENMs can cross or bypass the blood–brain barrier and then access the central nervous system and cause neurotoxicity. Until now, diverse in vivo and in vitro models have been developed to evaluate the neurotoxicity of ENMs, and oxidative stress, inflammation, DNA damage, and cell death have been identified as being involved. However, due to various physicochemical properties of ENMs and diverse study models in existing studies, it remains challenging to establish the structure-activity relationship of nanomaterials in neurotoxicity. In this paper, we aimed to review current studies on ENM-induced neurotoxicity, with an emphasis on the molecular and cellular mechanisms involved. We hope to provide a rational material design strategy for ENMs when they are applied in biomedical or other engineering applications.Keywords: engineered nanomaterials, neurotoxicity, oxidative stress, inflammation, DNA damage, cell deathGe DDu QRan BLiu XWang XMa XCheng FSun BDove Medical PressarticleEngineered NanomaterialsNeurotoxicityOxidative StressInflammationDNA DamageCell DeathMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4167-4186 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Engineered Nanomaterials Neurotoxicity Oxidative Stress Inflammation DNA Damage Cell Death Medicine (General) R5-920
spellingShingle	Engineered Nanomaterials Neurotoxicity Oxidative Stress Inflammation DNA Damage Cell Death Medicine (General) R5-920 Ge D Du Q Ran B Liu X Wang X Ma X Cheng F Sun B The neurotoxicity induced by engineered nanomaterials
description	Dan Ge,1,2,* Qiqi Du,1,2,* Bingqing Ran,1,2 Xingyu Liu,1,2 Xin Wang,1,2 Xuehu Ma,1 Fang Cheng,1,3 Bingbing Sun1,21State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, People’s Republic of China; 2Department of Chemical Engineering, Dalian University of Technology, Dalian 116024, People’s Republic of China; 3Department of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, People’s Republic of China*These authors contributed equally to this work Abstract: Engineered nanomaterials (ENMs) have been widely used in various fields due to their novel physicochemical properties. However, the use of ENMs has led to an increased exposure in humans, and the safety of ENMs has attracted much attention. It is universally acknowledged that ENMs could enter the human body via different routes, eg, inhalation, skin contact, and intravenous injection. Studies have proven that ENMs can cross or bypass the blood–brain barrier and then access the central nervous system and cause neurotoxicity. Until now, diverse in vivo and in vitro models have been developed to evaluate the neurotoxicity of ENMs, and oxidative stress, inflammation, DNA damage, and cell death have been identified as being involved. However, due to various physicochemical properties of ENMs and diverse study models in existing studies, it remains challenging to establish the structure-activity relationship of nanomaterials in neurotoxicity. In this paper, we aimed to review current studies on ENM-induced neurotoxicity, with an emphasis on the molecular and cellular mechanisms involved. We hope to provide a rational material design strategy for ENMs when they are applied in biomedical or other engineering applications.Keywords: engineered nanomaterials, neurotoxicity, oxidative stress, inflammation, DNA damage, cell death
format	article
author	Ge D Du Q Ran B Liu X Wang X Ma X Cheng F Sun B
author_facet	Ge D Du Q Ran B Liu X Wang X Ma X Cheng F Sun B
author_sort	Ge D
title	The neurotoxicity induced by engineered nanomaterials
title_short	The neurotoxicity induced by engineered nanomaterials
title_full	The neurotoxicity induced by engineered nanomaterials
title_fullStr	The neurotoxicity induced by engineered nanomaterials
title_full_unstemmed	The neurotoxicity induced by engineered nanomaterials
title_sort	neurotoxicity induced by engineered nanomaterials
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5225735374e741df93641aac78e22da2
work_keys_str_mv	AT ged theneurotoxicityinducedbyengineerednanomaterials AT duq theneurotoxicityinducedbyengineerednanomaterials AT ranb theneurotoxicityinducedbyengineerednanomaterials AT liux theneurotoxicityinducedbyengineerednanomaterials AT wangx theneurotoxicityinducedbyengineerednanomaterials AT max theneurotoxicityinducedbyengineerednanomaterials AT chengf theneurotoxicityinducedbyengineerednanomaterials AT sunb theneurotoxicityinducedbyengineerednanomaterials AT ged neurotoxicityinducedbyengineerednanomaterials AT duq neurotoxicityinducedbyengineerednanomaterials AT ranb neurotoxicityinducedbyengineerednanomaterials AT liux neurotoxicityinducedbyengineerednanomaterials AT wangx neurotoxicityinducedbyengineerednanomaterials AT max neurotoxicityinducedbyengineerednanomaterials AT chengf neurotoxicityinducedbyengineerednanomaterials AT sunb neurotoxicityinducedbyengineerednanomaterials
_version_	1718402648101617664

The neurotoxicity induced by engineered nanomaterials

Ejemplares similares