Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats

Background: There is a growing trend towards the use of medicinal plant that can prevent degeneration of pancreatic cells and regenerate islet cells in diabetes treatment. Objectives: The possible effects of the extracts of Spondias mombin leaves on the regeneration of pancreatic beta cells in st...

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Autores principales:	Nkeiruka Eluehike, Iyere Osolase Onoagbe
Formato:	article
Lenguaje:	EN
Publicado:	Hamadan University of Medical Sciences 2020
Materias:	pancreatic beta-cells s. mombin insulin c-peptide diabetes Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/522740d60d6e47e5a9922d31e3d7360c
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spelling	oai:doaj.org-article:522740d60d6e47e5a9922d31e3d7360c2021-11-20T08:40:03ZPreliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats10.34172/ajmb.2020.022345-4113https://doaj.org/article/522740d60d6e47e5a9922d31e3d7360c2020-06-01T00:00:00Zhttp://ajmb.umsha.ac.ir/PDF/ajmb-8-15.pdfhttps://doaj.org/toc/2345-4113Background: There is a growing trend towards the use of medicinal plant that can prevent degeneration of pancreatic cells and regenerate islet cells in diabetes treatment. Objectives: The possible effects of the extracts of Spondias mombin leaves on the regeneration of pancreatic beta cells in streptozotocin (STZ)-induced diabetic rats were determined in this study. Methods: Twenty-five male Wistar rats were randomly divided into 5 groups (A-E) including normal and diabetic rats. Aqueous and ethanol extracts of S. mombin were administered orally to diabetic rats in groups D and E for 12 weeks. Blood samples were collected for serum insulin and C-peptide assays. The pancreases were also collected for histopathological examination. Additionally, mineral and vitamin contents of the leaves were determined using standard procedures. Results: The highest vitamin content was vitamin C in the leaves, while the highest mineral content was calcium. Treatment with extracts of Spondias mombin attenuated the STZ-induced hypoinsulinemia, which was evident from the increased serum insulin and c-peptide levels in the extract treated groups. Histopathological examination of the pancreas revealed an increase in the number and size of the pancreatic beta cells in the extracts treated groups in comparison to the shrunken and diminished islet cells observed in the untreated animals. Conclusion: Extracts of S. mombin leaves are capable of regenerating pancreatic β-cells which were destroyed by streptozotocin induction.Nkeiruka EluehikeIyere Osolase OnoagbeHamadan University of Medical Sciencesarticlepancreatic beta-cellss. mombininsulinc-peptidediabetesMedical technologyR855-855.5ENAvicenna Journal of Medical Biochemistry, Vol 8, Iss 1, Pp 15-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic beta-cells s. mombin insulin c-peptide diabetes Medical technology R855-855.5
spellingShingle	pancreatic beta-cells s. mombin insulin c-peptide diabetes Medical technology R855-855.5 Nkeiruka Eluehike Iyere Osolase Onoagbe Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
description	Background: There is a growing trend towards the use of medicinal plant that can prevent degeneration of pancreatic cells and regenerate islet cells in diabetes treatment. Objectives: The possible effects of the extracts of Spondias mombin leaves on the regeneration of pancreatic beta cells in streptozotocin (STZ)-induced diabetic rats were determined in this study. Methods: Twenty-five male Wistar rats were randomly divided into 5 groups (A-E) including normal and diabetic rats. Aqueous and ethanol extracts of S. mombin were administered orally to diabetic rats in groups D and E for 12 weeks. Blood samples were collected for serum insulin and C-peptide assays. The pancreases were also collected for histopathological examination. Additionally, mineral and vitamin contents of the leaves were determined using standard procedures. Results: The highest vitamin content was vitamin C in the leaves, while the highest mineral content was calcium. Treatment with extracts of Spondias mombin attenuated the STZ-induced hypoinsulinemia, which was evident from the increased serum insulin and c-peptide levels in the extract treated groups. Histopathological examination of the pancreas revealed an increase in the number and size of the pancreatic beta cells in the extracts treated groups in comparison to the shrunken and diminished islet cells observed in the untreated animals. Conclusion: Extracts of S. mombin leaves are capable of regenerating pancreatic β-cells which were destroyed by streptozotocin induction.
format	article
author	Nkeiruka Eluehike Iyere Osolase Onoagbe
author_facet	Nkeiruka Eluehike Iyere Osolase Onoagbe
author_sort	Nkeiruka Eluehike
title	Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
title_short	Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
title_full	Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
title_fullStr	Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
title_full_unstemmed	Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats
title_sort	preliminary nutrient determination and regeneration of pancreatic islet cells by extracts of spondias mombin leaves in streptozotocin-induced diabetic rats
publisher	Hamadan University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/522740d60d6e47e5a9922d31e3d7360c
work_keys_str_mv	AT nkeirukaeluehike preliminarynutrientdeterminationandregenerationofpancreaticisletcellsbyextractsofspondiasmombinleavesinstreptozotocininduceddiabeticrats AT iyereosolaseonoagbe preliminarynutrientdeterminationandregenerationofpancreaticisletcellsbyextractsofspondiasmombinleavesinstreptozotocininduceddiabeticrats
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Preliminary Nutrient Determination and Regeneration of Pancreatic Islet Cells by Extracts of Spondias mombin Leaves in Streptozotocin-Induced Diabetic Rats

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