ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney...
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oai:doaj.org-article:5229b10863d246baa3bf20f7ad338a182021-11-18T08:03:37ZROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM1563-06252313-741X10.15789/1563-0625-2010-1-2-7-12https://doaj.org/article/5229b10863d246baa3bf20f7ad338a182014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/26https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.B. G. YushkovI. G. DanilovaI. A. PashninaI. A. BrykinaM. T. AbidovSPb RAACIarticlehematopoietic stem cellmacrophagemigrationregenerationtamerit treatmentImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 7-12 (2014) |
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DOAJ |
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hematopoietic stem cell macrophage migration regeneration tamerit treatment Immunologic diseases. Allergy RC581-607 |
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hematopoietic stem cell macrophage migration regeneration tamerit treatment Immunologic diseases. Allergy RC581-607 B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
description |
Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury. |
format |
article |
author |
B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov |
author_facet |
B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov |
author_sort |
B. G. Yushkov |
title |
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
title_short |
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
title_full |
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
title_fullStr |
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
title_full_unstemmed |
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM |
title_sort |
role of macrophages in regulation of hematopoietic stem cell migration in bone marrow peripheral blood system |
publisher |
SPb RAACI |
publishDate |
2014 |
url |
https://doaj.org/article/5229b10863d246baa3bf20f7ad338a18 |
work_keys_str_mv |
AT bgyushkov roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT igdanilova roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT iapashnina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT iabrykina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT mtabidov roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem |
_version_ |
1718422543738601472 |