ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM

Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney...

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Autores principales:	B. G. Yushkov, I. G. Danilova, I. A. Pashnina, I. A. Brykina, M. T. Abidov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hematopoietic stem cell macrophage migration regeneration tamerit treatment Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5229b10863d246baa3bf20f7ad338a18
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spelling	oai:doaj.org-article:5229b10863d246baa3bf20f7ad338a182021-11-18T08:03:37ZROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM1563-06252313-741X10.15789/1563-0625-2010-1-2-7-12https://doaj.org/article/5229b10863d246baa3bf20f7ad338a182014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/26https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.B. G. YushkovI. G. DanilovaI. A. PashninaI. A. BrykinaM. T. AbidovSPb RAACIarticlehematopoietic stem cellmacrophagemigrationregenerationtamerit treatmentImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 7-12 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hematopoietic stem cell macrophage migration regeneration tamerit treatment Immunologic diseases. Allergy RC581-607
spellingShingle	hematopoietic stem cell macrophage migration regeneration tamerit treatment Immunologic diseases. Allergy RC581-607 B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
description	Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.
format	article
author	B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov
author_facet	B. G. Yushkov I. G. Danilova I. A. Pashnina I. A. Brykina M. T. Abidov
author_sort	B. G. Yushkov
title	ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_short	ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_full	ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_fullStr	ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_full_unstemmed	ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_sort	role of macrophages in regulation of hematopoietic stem cell migration in bone marrow peripheral blood system
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5229b10863d246baa3bf20f7ad338a18
work_keys_str_mv	AT bgyushkov roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT igdanilova roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT iapashnina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT iabrykina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem AT mtabidov roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem
_version_	1718422543738601472

ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM

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