ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM

Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney...

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Autores principales: B. G. Yushkov, I. G. Danilova, I. A. Pashnina, I. A. Brykina, M. T. Abidov
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Lenguaje:RU
Publicado: SPb RAACI 2014
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Acceso en línea:https://doaj.org/article/5229b10863d246baa3bf20f7ad338a18
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spelling oai:doaj.org-article:5229b10863d246baa3bf20f7ad338a182021-11-18T08:03:37ZROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM1563-06252313-741X10.15789/1563-0625-2010-1-2-7-12https://doaj.org/article/5229b10863d246baa3bf20f7ad338a182014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/26https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.B. G. YushkovI. G. DanilovaI. A. PashninaI. A. BrykinaM. T. AbidovSPb RAACIarticlehematopoietic stem cellmacrophagemigrationregenerationtamerit treatmentImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 1-2, Pp 7-12 (2014)
institution DOAJ
collection DOAJ
language RU
topic hematopoietic stem cell
macrophage
migration
regeneration
tamerit treatment
Immunologic diseases. Allergy
RC581-607
spellingShingle hematopoietic stem cell
macrophage
migration
regeneration
tamerit treatment
Immunologic diseases. Allergy
RC581-607
B. G. Yushkov
I. G. Danilova
I. A. Pashnina
I. A. Brykina
M. T. Abidov
ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
description Mechanisms by which HSCs mobilize into damaged organs are currently under scrutiny.Macrophage role in these processes is investigated. In this study, we performed a flow cytometry analysis ofCD117+CD38+ and CD117+CD90low HSCs quantity in murine peripheral blood and bone marrow after liverand kidney injury under stimulation of phagocyte mononuclear system by injection of tamerit. This study havedemonstrated increased levels of CD117+CD38+ HSCs in bone marrow after partial hepatectomy, along withtheir migration to peripheral blood in response to tamerit injection. We also demonstrated that peripheralblood CD117+CD38+ HSCs levels were elevated after kidney injury. After partial hepatectomy, nochangesof CD117+CD90low HSCs quantity in investigated tissues were detected. We observed increased number ofCD117+CD90low HSCs in murine blood following kidney injury. Thus, we observed different influence ofmacrophage stimulation on the quantity of CD117+CD38+ and CD117+CD90low cells. These data suggestthat HSCs mobilization from the bone marrow to peripheral blood depends, at least in part, on phagocytemononuclear system, and that macrophage stimulation is important for proliferation and migration of variousHSCs populations following liver and kidney injury.
format article
author B. G. Yushkov
I. G. Danilova
I. A. Pashnina
I. A. Brykina
M. T. Abidov
author_facet B. G. Yushkov
I. G. Danilova
I. A. Pashnina
I. A. Brykina
M. T. Abidov
author_sort B. G. Yushkov
title ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_short ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_full ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_fullStr ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_full_unstemmed ROLE OF MACROPHAGES IN REGULATION OF HEMATOPOIETIC STEM CELL MIGRATION IN BONE MARROW PERIPHERAL BLOOD SYSTEM
title_sort role of macrophages in regulation of hematopoietic stem cell migration in bone marrow peripheral blood system
publisher SPb RAACI
publishDate 2014
url https://doaj.org/article/5229b10863d246baa3bf20f7ad338a18
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AT iapashnina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem
AT iabrykina roleofmacrophagesinregulationofhematopoieticstemcellmigrationinbonemarrowperipheralbloodsystem
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