Accelerated Degradation of polymeric surgical suture materials

The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-conditions to degrade PDO films within four weeks. Therefore the de...

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Autores principales:	Reske Thomas, Eickner Thomas, Grabow Niels, Schmitz Klaus-Peter, Siewert Stefan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	biodegradable polydioxanone poly lactic-coglycolic acid accelerated degradation alkaline Medicine R
Acceso en línea:	https://doaj.org/article/522cfc3a20994879afe97cef3b54cc08
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spelling	oai:doaj.org-article:522cfc3a20994879afe97cef3b54cc082021-12-05T14:10:43ZAccelerated Degradation of polymeric surgical suture materials2364-550410.1515/cdbme-2020-3118https://doaj.org/article/522cfc3a20994879afe97cef3b54cc082020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3118https://doaj.org/toc/2364-5504The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-conditions to degrade PDO films within four weeks. Therefore the degradation of PDO was performed in accelerated conditions in tempered alkaline glycine NaOH buffer. Molecular weight and mass loss were studied. PDO results were compared with poly lactic-co-glycolic acid P(LLA-co-GA).Reske ThomasEickner ThomasGrabow NielsSchmitz Klaus-PeterSiewert StefanDe Gruyterarticlebiodegradable polydioxanonepoly lactic-coglycolic acidaccelerated degradationalkalineMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 458-460 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	biodegradable polydioxanone poly lactic-coglycolic acid accelerated degradation alkaline Medicine R
spellingShingle	biodegradable polydioxanone poly lactic-coglycolic acid accelerated degradation alkaline Medicine R Reske Thomas Eickner Thomas Grabow Niels Schmitz Klaus-Peter Siewert Stefan Accelerated Degradation of polymeric surgical suture materials
description	The degradable polymer Polydioxanone (PDO) is used for medical implants since 1981. Manufacturers state a degradation timeframe of <180 days or an absorption duration of 182-238 days [1, 2]. Aim of this study was to find in vitro-conditions to degrade PDO films within four weeks. Therefore the degradation of PDO was performed in accelerated conditions in tempered alkaline glycine NaOH buffer. Molecular weight and mass loss were studied. PDO results were compared with poly lactic-co-glycolic acid P(LLA-co-GA).
format	article
author	Reske Thomas Eickner Thomas Grabow Niels Schmitz Klaus-Peter Siewert Stefan
author_facet	Reske Thomas Eickner Thomas Grabow Niels Schmitz Klaus-Peter Siewert Stefan
author_sort	Reske Thomas
title	Accelerated Degradation of polymeric surgical suture materials
title_short	Accelerated Degradation of polymeric surgical suture materials
title_full	Accelerated Degradation of polymeric surgical suture materials
title_fullStr	Accelerated Degradation of polymeric surgical suture materials
title_full_unstemmed	Accelerated Degradation of polymeric surgical suture materials
title_sort	accelerated degradation of polymeric surgical suture materials
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/522cfc3a20994879afe97cef3b54cc08
work_keys_str_mv	AT reskethomas accelerateddegradationofpolymericsurgicalsuturematerials AT eicknerthomas accelerateddegradationofpolymericsurgicalsuturematerials AT grabowniels accelerateddegradationofpolymericsurgicalsuturematerials AT schmitzklauspeter accelerateddegradationofpolymericsurgicalsuturematerials AT siewertstefan accelerateddegradationofpolymericsurgicalsuturematerials
_version_	1718371786008035328

Accelerated Degradation of polymeric surgical suture materials

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