LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors show that LRRC8 volume-regulated anion channels (VRACs...

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Autores principales:	Till Stuhlmann, Rosa Planells-Cases, Thomas J. Jentsch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/522fb48cb1dc42bd81e0cdee18ac8bb0
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spelling	oai:doaj.org-article:522fb48cb1dc42bd81e0cdee18ac8bb02021-12-02T15:33:59ZLRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion10.1038/s41467-018-04353-y2041-1723https://doaj.org/article/522fb48cb1dc42bd81e0cdee18ac8bb02018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04353-yhttps://doaj.org/toc/2041-1723Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors show that LRRC8 volume-regulated anion channels (VRACs) modulate glucose-stimulated calcium increase and insulin secretion.Till StuhlmannRosa Planells-CasesThomas J. JentschNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Till Stuhlmann Rosa Planells-Cases Thomas J. Jentsch LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
description	Insulin secretion by β-cells is stimulated by glucose and is dependent on the induction of β-cell membrane depolarization, mainly driven by the closure of KATP channels, which in turn promotes voltage-gated Ca2+ channel opening. Here the authors show that LRRC8 volume-regulated anion channels (VRACs) modulate glucose-stimulated calcium increase and insulin secretion.
format	article
author	Till Stuhlmann Rosa Planells-Cases Thomas J. Jentsch
author_facet	Till Stuhlmann Rosa Planells-Cases Thomas J. Jentsch
author_sort	Till Stuhlmann
title	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
title_short	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
title_full	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
title_fullStr	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
title_full_unstemmed	LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion
title_sort	lrrc8/vrac anion channels enhance β-cell glucose sensing and insulin secretion
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/522fb48cb1dc42bd81e0cdee18ac8bb0
work_keys_str_mv	AT tillstuhlmann lrrc8vracanionchannelsenhancebcellglucosesensingandinsulinsecretion AT rosaplanellscases lrrc8vracanionchannelsenhancebcellglucosesensingandinsulinsecretion AT thomasjjentsch lrrc8vracanionchannelsenhancebcellglucosesensingandinsulinsecretion
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LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

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