Decompression effects on bone healing in rat mandible osteomyelitis

Abstract Osteomyelitis (OM) of the jaw is usually caused by a chronic odontogenic infection. Decompression is the release the intraluminal pressure in the cystic cavity allowing gradual bone growth from the periphery. The aim of this study was to analyze the effectiveness of decompression in an OM j...

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Autores principales:	Buyanbileg Sodnom-Ish, Mi Young Eo, Ji Hye Oh, Mi Hyun Seo, Hoon Joo Yang, Jong Ho Lee, Soung Min Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/52311e4ab2f948e2b6294e6db9db01d6
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spelling	oai:doaj.org-article:52311e4ab2f948e2b6294e6db9db01d62021-12-02T15:57:11ZDecompression effects on bone healing in rat mandible osteomyelitis10.1038/s41598-021-91104-72045-2322https://doaj.org/article/52311e4ab2f948e2b6294e6db9db01d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91104-7https://doaj.org/toc/2045-2322Abstract Osteomyelitis (OM) of the jaw is usually caused by a chronic odontogenic infection. Decompression is the release the intraluminal pressure in the cystic cavity allowing gradual bone growth from the periphery. The aim of this study was to analyze the effectiveness of decompression in an OM jaw model. A 4-mm-diameter defect was made on mandibles of fourteen Sprague–Dawley rats and inoculated with S. aureus (20 μl of 1 × 107 CFU/ml) injection. Two weeks later, four groups were made as non-treatment (C1), only curettage (C2), curettage and decompression (E1), and curettage and decompression with normal saline irrigation (E2). After four weeks, each group was analyzed. Most micro-CT parameters, including bone mineral density [0.87 (± 0.08) g/cm3] with bone volume [0.73 (± 0.08) mm3] was higher in E2 group than that of C1 group (p = 0.04, p = 0.05, respectively). E2 group in histology showed the highest number of osteocytes than those of control groups, 91.00 (± 9.90) (p = 0.002). OPN were expressed strongly in the E1 (“5”: 76–100%) that those of other groups. Decompression drains induced advanced bone healing compared to that of curettage alone. Therefore, it could be recommended to use decompressive drain for enhancing the jaw OM management.Buyanbileg Sodnom-IshMi Young EoJi Hye OhMi Hyun SeoHoon Joo YangJong Ho LeeSoung Min KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Buyanbileg Sodnom-Ish Mi Young Eo Ji Hye Oh Mi Hyun Seo Hoon Joo Yang Jong Ho Lee Soung Min Kim Decompression effects on bone healing in rat mandible osteomyelitis
description	Abstract Osteomyelitis (OM) of the jaw is usually caused by a chronic odontogenic infection. Decompression is the release the intraluminal pressure in the cystic cavity allowing gradual bone growth from the periphery. The aim of this study was to analyze the effectiveness of decompression in an OM jaw model. A 4-mm-diameter defect was made on mandibles of fourteen Sprague–Dawley rats and inoculated with S. aureus (20 μl of 1 × 107 CFU/ml) injection. Two weeks later, four groups were made as non-treatment (C1), only curettage (C2), curettage and decompression (E1), and curettage and decompression with normal saline irrigation (E2). After four weeks, each group was analyzed. Most micro-CT parameters, including bone mineral density [0.87 (± 0.08) g/cm3] with bone volume [0.73 (± 0.08) mm3] was higher in E2 group than that of C1 group (p = 0.04, p = 0.05, respectively). E2 group in histology showed the highest number of osteocytes than those of control groups, 91.00 (± 9.90) (p = 0.002). OPN were expressed strongly in the E1 (“5”: 76–100%) that those of other groups. Decompression drains induced advanced bone healing compared to that of curettage alone. Therefore, it could be recommended to use decompressive drain for enhancing the jaw OM management.
format	article
author	Buyanbileg Sodnom-Ish Mi Young Eo Ji Hye Oh Mi Hyun Seo Hoon Joo Yang Jong Ho Lee Soung Min Kim
author_facet	Buyanbileg Sodnom-Ish Mi Young Eo Ji Hye Oh Mi Hyun Seo Hoon Joo Yang Jong Ho Lee Soung Min Kim
author_sort	Buyanbileg Sodnom-Ish
title	Decompression effects on bone healing in rat mandible osteomyelitis
title_short	Decompression effects on bone healing in rat mandible osteomyelitis
title_full	Decompression effects on bone healing in rat mandible osteomyelitis
title_fullStr	Decompression effects on bone healing in rat mandible osteomyelitis
title_full_unstemmed	Decompression effects on bone healing in rat mandible osteomyelitis
title_sort	decompression effects on bone healing in rat mandible osteomyelitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/52311e4ab2f948e2b6294e6db9db01d6
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Decompression effects on bone healing in rat mandible osteomyelitis

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