From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System

The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding of autonomic control of the heart has drastically improved, and the IcNS is increasingly being...

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Autores principales:	Matthew R. Stoyek, Luis Hortells, T. Alexander Quinn
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurocardiology sympathetic parasympathetic mammal zebrafish cell culture Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/5235a03be618446f84ecaeced7fba84d
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spelling	oai:doaj.org-article:5235a03be618446f84ecaeced7fba84d2021-11-25T18:00:21ZFrom Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System10.3390/jcdd81101492308-3425https://doaj.org/article/5235a03be618446f84ecaeced7fba84d2021-11-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/149https://doaj.org/toc/2308-3425The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding of autonomic control of the heart has drastically improved, and the IcNS is increasingly being viewed as a therapeutic target in cardiovascular disease. However, investigations of the physiology and specific roles of intracardiac neurons within the neural circuitry mediating cardiac control has been hampered by an incomplete knowledge of the anatomical organisation of the IcNS. A more thorough understanding of the IcNS is hoped to promote the development of new, highly targeted therapies to modulate IcNS activity in cardiovascular disease. In this paper, we first provide an overview of IcNS anatomy and function derived from experiments in mammals. We then provide descriptions of alternate experimental models for investigation of the IcNS, focusing on a non-mammalian model (zebrafish), neuron-cardiomyocyte co-cultures, and computational models to demonstrate how the similarity of the relevant processes in each model can help to further our understanding of the IcNS in health and disease.Matthew R. StoyekLuis HortellsT. Alexander QuinnMDPI AGarticleneurocardiologysympatheticparasympatheticmammalzebrafishcell cultureDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 149, p 149 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurocardiology sympathetic parasympathetic mammal zebrafish cell culture Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	neurocardiology sympathetic parasympathetic mammal zebrafish cell culture Diseases of the circulatory (Cardiovascular) system RC666-701 Matthew R. Stoyek Luis Hortells T. Alexander Quinn From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
description	The intracardiac nervous system (IcNS), sometimes referred to as the “little brain” of the heart, is involved in modulating many aspects of cardiac physiology. In recent years our fundamental understanding of autonomic control of the heart has drastically improved, and the IcNS is increasingly being viewed as a therapeutic target in cardiovascular disease. However, investigations of the physiology and specific roles of intracardiac neurons within the neural circuitry mediating cardiac control has been hampered by an incomplete knowledge of the anatomical organisation of the IcNS. A more thorough understanding of the IcNS is hoped to promote the development of new, highly targeted therapies to modulate IcNS activity in cardiovascular disease. In this paper, we first provide an overview of IcNS anatomy and function derived from experiments in mammals. We then provide descriptions of alternate experimental models for investigation of the IcNS, focusing on a non-mammalian model (zebrafish), neuron-cardiomyocyte co-cultures, and computational models to demonstrate how the similarity of the relevant processes in each model can help to further our understanding of the IcNS in health and disease.
format	article
author	Matthew R. Stoyek Luis Hortells T. Alexander Quinn
author_facet	Matthew R. Stoyek Luis Hortells T. Alexander Quinn
author_sort	Matthew R. Stoyek
title	From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
title_short	From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
title_full	From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
title_fullStr	From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
title_full_unstemmed	From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System
title_sort	from mice to mainframes: experimental models for investigation of the intracardiac nervous system
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5235a03be618446f84ecaeced7fba84d
work_keys_str_mv	AT matthewrstoyek frommicetomainframesexperimentalmodelsforinvestigationoftheintracardiacnervoussystem AT luishortells frommicetomainframesexperimentalmodelsforinvestigationoftheintracardiacnervoussystem AT talexanderquinn frommicetomainframesexperimentalmodelsforinvestigationoftheintracardiacnervoussystem
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From Mice to Mainframes: Experimental Models for Investigation of the Intracardiac Nervous System

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