Clinical results of Trabectome surgery for open-angle glaucoma

Clinical results of Trabectome surgery for open-angle glaucoma

Takanori Mizoguchi,1 Shiro Nishigaki,2 Tomoki Sato,3 Harumi Wakiyama,4 Nobuchika Ogino2 1Mizoguchi Eye Clinic, Ophthalmology, Sasebo, 2Nishigaki Eye Clinic, Ophthalmology, Nagoya, 3Sato Eye Clinic, Ophthalmology, Arao, 4Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan Background: The...

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Autores principales: Mizoguchi T, Nishigaki S, Sato T, Wakiyama H, Ogino N
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/5238d04613234a0b86267630fbf5c86a
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spelling oai:doaj.org-article:5238d04613234a0b86267630fbf5c86a2021-12-02T05:09:24ZClinical results of Trabectome surgery for open-angle glaucoma1177-5483https://doaj.org/article/5238d04613234a0b86267630fbf5c86a2015-10-01T00:00:00Zhttps://www.dovepress.com/clinical-results-of-trabectome-surgery-for-open-angle-glaucoma-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Takanori Mizoguchi,1 Shiro Nishigaki,2 Tomoki Sato,3 Harumi Wakiyama,4 Nobuchika Ogino2 1Mizoguchi Eye Clinic, Ophthalmology, Sasebo, 2Nishigaki Eye Clinic, Ophthalmology, Nagoya, 3Sato Eye Clinic, Ophthalmology, Arao, 4Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan Background: The purpose of this study was to determine outcomes when using Trabectome surgery and to evaluate factors associated with its effects in primary open-angle glaucoma (POAG) and exfoliation glaucoma (EXG). Methods: This was a prospective, non-randomized, observational, comparative cohort study in which Trabectome surgery was used alone in patients with POAG or EXG. Trabectome surgery was considered to have failed when at least one of the following three criteria was fulfilled: intraocular pressure (IOP) ≥21 mmHg and a <20% reduction below the baseline IOP on two consecutive follow-up visits 3 months or more after surgery; need for additional glaucoma surgery; and an increase in number of medications compared with baseline. Results: The subjects were 32 males (34 eyes) and 46 females (48 eyes). POAG was observed in 43 eyes and EXG in 39 eyes. IOP after Trabectome surgery decreased significantly from 22.3±6.8 mmHg at baseline to 14.0±3.9 mmHg (23.0% reduction) at month 24 in all cases (P<0.0000). The success rate at 2 years was 51.2% for all cases (POAG, 50.9%; EXG, 49.2%). There was no significant difference in success rate between POAG and EXG (P=0.91). Preoperative IOP (P=0.033) and number of medications (P=0.041) were significant factors for surgical success/failure in multivariate logistic regression. No serious complications were observed. Conclusion: Trabectome surgery achieved favorable IOP control and was equally effective in patients with POAG and those with EXG. Its effects were influenced by preoperative IOP and number of preoperative medications. Keywords: Trabectome, primary open-angle glaucoma, exfoliation glaucoma, success rate, risk factors Mizoguchi TNishigaki SSato TWakiyama HOgino NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 1889-1894 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Mizoguchi T
Nishigaki S
Sato T
Wakiyama H
Ogino N
Clinical results of Trabectome surgery for open-angle glaucoma
description Takanori Mizoguchi,1 Shiro Nishigaki,2 Tomoki Sato,3 Harumi Wakiyama,4 Nobuchika Ogino2 1Mizoguchi Eye Clinic, Ophthalmology, Sasebo, 2Nishigaki Eye Clinic, Ophthalmology, Nagoya, 3Sato Eye Clinic, Ophthalmology, Arao, 4Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki, Japan Background: The purpose of this study was to determine outcomes when using Trabectome surgery and to evaluate factors associated with its effects in primary open-angle glaucoma (POAG) and exfoliation glaucoma (EXG). Methods: This was a prospective, non-randomized, observational, comparative cohort study in which Trabectome surgery was used alone in patients with POAG or EXG. Trabectome surgery was considered to have failed when at least one of the following three criteria was fulfilled: intraocular pressure (IOP) ≥21 mmHg and a <20% reduction below the baseline IOP on two consecutive follow-up visits 3 months or more after surgery; need for additional glaucoma surgery; and an increase in number of medications compared with baseline. Results: The subjects were 32 males (34 eyes) and 46 females (48 eyes). POAG was observed in 43 eyes and EXG in 39 eyes. IOP after Trabectome surgery decreased significantly from 22.3±6.8 mmHg at baseline to 14.0±3.9 mmHg (23.0% reduction) at month 24 in all cases (P<0.0000). The success rate at 2 years was 51.2% for all cases (POAG, 50.9%; EXG, 49.2%). There was no significant difference in success rate between POAG and EXG (P=0.91). Preoperative IOP (P=0.033) and number of medications (P=0.041) were significant factors for surgical success/failure in multivariate logistic regression. No serious complications were observed. Conclusion: Trabectome surgery achieved favorable IOP control and was equally effective in patients with POAG and those with EXG. Its effects were influenced by preoperative IOP and number of preoperative medications. Keywords: Trabectome, primary open-angle glaucoma, exfoliation glaucoma, success rate, risk factors 
format article
author Mizoguchi T
Nishigaki S
Sato T
Wakiyama H
Ogino N
author_facet Mizoguchi T
Nishigaki S
Sato T
Wakiyama H
Ogino N
author_sort Mizoguchi T
title Clinical results of Trabectome surgery for open-angle glaucoma
title_short Clinical results of Trabectome surgery for open-angle glaucoma
title_full Clinical results of Trabectome surgery for open-angle glaucoma
title_fullStr Clinical results of Trabectome surgery for open-angle glaucoma
title_full_unstemmed Clinical results of Trabectome surgery for open-angle glaucoma
title_sort clinical results of trabectome surgery for open-angle glaucoma
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/5238d04613234a0b86267630fbf5c86a
work_keys_str_mv AT mizoguchit clinicalresultsoftrabectomesurgeryforopenangleglaucoma
AT nishigakis clinicalresultsoftrabectomesurgeryforopenangleglaucoma
AT satot clinicalresultsoftrabectomesurgeryforopenangleglaucoma
AT wakiyamah clinicalresultsoftrabectomesurgeryforopenangleglaucoma
AT oginon clinicalresultsoftrabectomesurgeryforopenangleglaucoma
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