Diversifying the structure of zinc finger nucleases for high-precision genome editing

Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at loci of therapeutic significance.

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Detalles Bibliográficos
Autores principales:	David E. Paschon, Stephanie Lussier, Tenzin Wangzor, Danny F. Xia, Patrick W. Li, Sarah J. Hinkley, Nicholas A. Scarlott, Stephen C. Lam, Adam J. Waite, Lynn N. Truong, Nimisha Gandhi, Bhakti N. Kadam, Deepak P. Patil, David A. Shivak, Gary K. Lee, Michael C. Holmes, Lei Zhang, Jeffrey C. Miller, Edward J. Rebar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/52399a6682884a7196ea64923e436811
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spelling	oai:doaj.org-article:52399a6682884a7196ea64923e4368112021-12-02T14:35:31ZDiversifying the structure of zinc finger nucleases for high-precision genome editing10.1038/s41467-019-08867-x2041-1723https://doaj.org/article/52399a6682884a7196ea64923e4368112019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08867-xhttps://doaj.org/toc/2041-1723Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at loci of therapeutic significance.David E. PaschonStephanie LussierTenzin WangzorDanny F. XiaPatrick W. LiSarah J. HinkleyNicholas A. ScarlottStephen C. LamAdam J. WaiteLynn N. TruongNimisha GandhiBhakti N. KadamDeepak P. PatilDavid A. ShivakGary K. LeeMichael C. HolmesLei ZhangJeffrey C. MillerEdward J. RebarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David E. Paschon Stephanie Lussier Tenzin Wangzor Danny F. Xia Patrick W. Li Sarah J. Hinkley Nicholas A. Scarlott Stephen C. Lam Adam J. Waite Lynn N. Truong Nimisha Gandhi Bhakti N. Kadam Deepak P. Patil David A. Shivak Gary K. Lee Michael C. Holmes Lei Zhang Jeffrey C. Miller Edward J. Rebar Diversifying the structure of zinc finger nucleases for high-precision genome editing
description	Genome editing often requires cleavage within a narrow sequence window. Here the authors develop an expanded set of zinc finger nuclease architectures that increase the available configurations by a factor of 64 and can target almost every base at loci of therapeutic significance.
format	article
author	David E. Paschon Stephanie Lussier Tenzin Wangzor Danny F. Xia Patrick W. Li Sarah J. Hinkley Nicholas A. Scarlott Stephen C. Lam Adam J. Waite Lynn N. Truong Nimisha Gandhi Bhakti N. Kadam Deepak P. Patil David A. Shivak Gary K. Lee Michael C. Holmes Lei Zhang Jeffrey C. Miller Edward J. Rebar
author_facet	David E. Paschon Stephanie Lussier Tenzin Wangzor Danny F. Xia Patrick W. Li Sarah J. Hinkley Nicholas A. Scarlott Stephen C. Lam Adam J. Waite Lynn N. Truong Nimisha Gandhi Bhakti N. Kadam Deepak P. Patil David A. Shivak Gary K. Lee Michael C. Holmes Lei Zhang Jeffrey C. Miller Edward J. Rebar
author_sort	David E. Paschon
title	Diversifying the structure of zinc finger nucleases for high-precision genome editing
title_short	Diversifying the structure of zinc finger nucleases for high-precision genome editing
title_full	Diversifying the structure of zinc finger nucleases for high-precision genome editing
title_fullStr	Diversifying the structure of zinc finger nucleases for high-precision genome editing
title_full_unstemmed	Diversifying the structure of zinc finger nucleases for high-precision genome editing
title_sort	diversifying the structure of zinc finger nucleases for high-precision genome editing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/52399a6682884a7196ea64923e436811
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Diversifying the structure of zinc finger nucleases for high-precision genome editing

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