Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study

Background: <i>Listeria monocytogenes</i> (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastro...

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Autores principales:	Shang-Hsuan Huang, Ming-Shun Hsieh, Sung-Yuan Hu, Shih-Che Huang, Che-An Tsai, Chiann-Yi Hsu, Tzu-Chieh Lin, Yi-Chen Lee, Shu-Hui Liao
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	area under the curve (AUC) bacteremia <i>Listeria monocytogenes</i> (LM) mortality in emergency department sepsis (MEDS) score national early warning score (NEWS) scoring systems Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/523b3dce7f664d3caebea0876ec63815
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spelling	oai:doaj.org-article:523b3dce7f664d3caebea0876ec638152021-11-25T16:46:45ZPerformance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study10.3390/biology101110732079-7737https://doaj.org/article/523b3dce7f664d3caebea0876ec638152021-10-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1073https://doaj.org/toc/2079-7737Background: <i>Listeria monocytogenes</i> (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastrointestinal symptoms. However, immunocompromised elderly people, pregnant women, and newborns may develop life-threatening invasive infections. The mortality rate of LM infection is as high as 25–30%. The aim of this study is to investigate clinical scores of patients with bacteremia of LM confirmed by one or more blood cultures. We analyzed their demographics and laboratory findings in relation to their clinical outcomes. Materials and Methods: This was a hospital-based retrospective study on patients with bacteremia of LM. Data were collected from the electronic clinical database of Taichung Veterans General Hospital between January 2012 and December 2020. Bacteremia of LM was confirmed by at least one blood culture. Demographics, clinical characteristics, and laboratory data were collected for analysis. A variety of clinical scoring systems were used to predict the clinical outcome. Results: A total of 39 patients had confirmed bacteremia of LM. Among them, 1 neonatal patient was excluded. The remaining 38 patients were studied. They included 16 males (42.1%) and 22 females (57.9%), with a mean age of 59.9 ± 19.6 years. Their hospital stay averaged 23.3 ± 20.9 days. The in-hospital mortality rate was 36.8%. Mortality in Emergency Department Sepsis (MEDS) Score was 6.6 ± 4.0 for survivors and 12.4 ± 4.4 for non-survivors (P < 0.001). The National Early Warning Score (NEWS) was 3.9 ± 2.8 for survivors and 7.8 ± 3.1 for non-survivors (P = 0.001). Regarding the prediction of mortality risk, the AUC of ROC was 0.829 for MEDS and 0.815 for NEWS. Conclusions: MEDS and NEWS were both good predictors of the clinical outcome in LM bacteremic patients. In those with higher scores of MEDS (≥10) and NEWS (≥8), we recommended an early goal-directed therapy and appropriate antibiotic treatment as early as possible to reduce mortality. Further large-scale studies are required to gain a deeper understanding of this disease and to ensure patient safety.Shang-Hsuan HuangMing-Shun HsiehSung-Yuan HuShih-Che HuangChe-An TsaiChiann-Yi HsuTzu-Chieh LinYi-Chen LeeShu-Hui LiaoMDPI AGarticlearea under the curve (AUC)bacteremia<i>Listeria monocytogenes</i> (LM)mortality in emergency department sepsis (MEDS) scorenational early warning score (NEWS)scoring systemsBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1073, p 1073 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	area under the curve (AUC) bacteremia <i>Listeria monocytogenes</i> (LM) mortality in emergency department sepsis (MEDS) score national early warning score (NEWS) scoring systems Biology (General) QH301-705.5
spellingShingle	area under the curve (AUC) bacteremia <i>Listeria monocytogenes</i> (LM) mortality in emergency department sepsis (MEDS) score national early warning score (NEWS) scoring systems Biology (General) QH301-705.5 Shang-Hsuan Huang Ming-Shun Hsieh Sung-Yuan Hu Shih-Che Huang Che-An Tsai Chiann-Yi Hsu Tzu-Chieh Lin Yi-Chen Lee Shu-Hui Liao Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
description	Background: <i>Listeria monocytogenes</i> (LM) is a facultative anaerobe, Gram-positive bacillus which is widely distributed in nature, and can be separated from soil, water, and rotten vegetables. Immunocompetent people are less likely to suffer from LM infection or may only show gastrointestinal symptoms. However, immunocompromised elderly people, pregnant women, and newborns may develop life-threatening invasive infections. The mortality rate of LM infection is as high as 25–30%. The aim of this study is to investigate clinical scores of patients with bacteremia of LM confirmed by one or more blood cultures. We analyzed their demographics and laboratory findings in relation to their clinical outcomes. Materials and Methods: This was a hospital-based retrospective study on patients with bacteremia of LM. Data were collected from the electronic clinical database of Taichung Veterans General Hospital between January 2012 and December 2020. Bacteremia of LM was confirmed by at least one blood culture. Demographics, clinical characteristics, and laboratory data were collected for analysis. A variety of clinical scoring systems were used to predict the clinical outcome. Results: A total of 39 patients had confirmed bacteremia of LM. Among them, 1 neonatal patient was excluded. The remaining 38 patients were studied. They included 16 males (42.1%) and 22 females (57.9%), with a mean age of 59.9 ± 19.6 years. Their hospital stay averaged 23.3 ± 20.9 days. The in-hospital mortality rate was 36.8%. Mortality in Emergency Department Sepsis (MEDS) Score was 6.6 ± 4.0 for survivors and 12.4 ± 4.4 for non-survivors (P < 0.001). The National Early Warning Score (NEWS) was 3.9 ± 2.8 for survivors and 7.8 ± 3.1 for non-survivors (P = 0.001). Regarding the prediction of mortality risk, the AUC of ROC was 0.829 for MEDS and 0.815 for NEWS. Conclusions: MEDS and NEWS were both good predictors of the clinical outcome in LM bacteremic patients. In those with higher scores of MEDS (≥10) and NEWS (≥8), we recommended an early goal-directed therapy and appropriate antibiotic treatment as early as possible to reduce mortality. Further large-scale studies are required to gain a deeper understanding of this disease and to ensure patient safety.
format	article
author	Shang-Hsuan Huang Ming-Shun Hsieh Sung-Yuan Hu Shih-Che Huang Che-An Tsai Chiann-Yi Hsu Tzu-Chieh Lin Yi-Chen Lee Shu-Hui Liao
author_facet	Shang-Hsuan Huang Ming-Shun Hsieh Sung-Yuan Hu Shih-Che Huang Che-An Tsai Chiann-Yi Hsu Tzu-Chieh Lin Yi-Chen Lee Shu-Hui Liao
author_sort	Shang-Hsuan Huang
title	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
title_short	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
title_full	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
title_fullStr	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
title_full_unstemmed	Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study
title_sort	performance of scoring systems in predicting clinical outcomes in patients with bacteremia of <i>listeria monocytogenes</i>: a 9-year hospital-based study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/523b3dce7f664d3caebea0876ec63815
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Performance of Scoring Systems in Predicting Clinical Outcomes in Patients with Bacteremia of <i>Listeria monocytogenes</i>: A 9-Year Hospital-Based Study

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