A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients

Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that improves the patients’ anemia and lifespan, but it may lead to iron overload in parenchymal tissue organs and endocrine glands that cause their dysfunctions as the iron regulatory system can’t excrete excess iro...

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Autores principales:	Morteza Arab-Zozani, Setare Kheyrandish, Amirhossein Rastgar, Ebrahim Miri-Moghadam
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2021
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/523e3822da984ffb9f001b722ccd1583
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spelling	oai:doaj.org-article:523e3822da984ffb9f001b722ccd15832021-12-02T16:12:14ZA Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients2214-999610.5334/aogh.3184https://doaj.org/article/523e3822da984ffb9f001b722ccd15832021-06-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/3184https://doaj.org/toc/2214-9996Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that improves the patients’ anemia and lifespan, but it may lead to iron overload in parenchymal tissue organs and endocrine glands that cause their dysfunctions as the iron regulatory system can’t excrete excess iron from the bloodstream. Objective: To evaluate the prevalence of iron-related complications (short stature, growth retardation, and growth hormone deficiency) in β-thalassemia major (βTM) patients. Methods: We performed an electronic search in PubMed, Scopus, and Web of Sciences to evaluate the prevalence of growth hormone impairment in β-thalassemia major (βTM) patients worldwide. Qualities of eligible studies were assessed by the Joanna Briggs Institute checklist for the prevalence study. We used Comprehensive Meta-Analysis (Version 2) to calculate the event rate with 95% CIs, using a random-effects model for all analyses. Findings: Seventy–four studies were included from five continents between 1978 and 2019; 70.27% (Asia), 16.21% (Europe), 6.75% (Africa), 2.70% (America), 1.35% (Oceania), and 2.70% (Multicenter). The overall mean age of the participants was about 14 years. The pooled prevalence of short stature (ST) was 48.9% (95% CI 35.3–62.6) and in male was higher than female (61.9%, 95% CI 53.4–69.7 vs. 50.9%, CI 41.8–59.9). The pooled prevalence of growth retardation (GR) was 41.1% and in male was higher than in female (51.6%, 95% CI 17.8–84 vs. 33.1%, CI 9.4–70.2). The pooled prevalence of growth hormone deficiency (GHD) was 26.6% (95% CI 16–40.8). Conclusion: Our study revealed that near half of thalassemia patients suffer from growth impairments. However, regular evaluation of serum ferritin levels, close monitoring in a proper institute, suitable and acceptable treatment methods besides regular chelation therapy could significantly reduce the patients’ complications.Morteza Arab-ZozaniSetare KheyrandishAmirhossein RastgarEbrahim Miri-MoghadamUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 87, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Morteza Arab-Zozani Setare Kheyrandish Amirhossein Rastgar Ebrahim Miri-Moghadam A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
description	Background: Blood transfusion is a traditional treatment for β-thalassemia (β-thal) that improves the patients’ anemia and lifespan, but it may lead to iron overload in parenchymal tissue organs and endocrine glands that cause their dysfunctions as the iron regulatory system can’t excrete excess iron from the bloodstream. Objective: To evaluate the prevalence of iron-related complications (short stature, growth retardation, and growth hormone deficiency) in β-thalassemia major (βTM) patients. Methods: We performed an electronic search in PubMed, Scopus, and Web of Sciences to evaluate the prevalence of growth hormone impairment in β-thalassemia major (βTM) patients worldwide. Qualities of eligible studies were assessed by the Joanna Briggs Institute checklist for the prevalence study. We used Comprehensive Meta-Analysis (Version 2) to calculate the event rate with 95% CIs, using a random-effects model for all analyses. Findings: Seventy–four studies were included from five continents between 1978 and 2019; 70.27% (Asia), 16.21% (Europe), 6.75% (Africa), 2.70% (America), 1.35% (Oceania), and 2.70% (Multicenter). The overall mean age of the participants was about 14 years. The pooled prevalence of short stature (ST) was 48.9% (95% CI 35.3–62.6) and in male was higher than female (61.9%, 95% CI 53.4–69.7 vs. 50.9%, CI 41.8–59.9). The pooled prevalence of growth retardation (GR) was 41.1% and in male was higher than in female (51.6%, 95% CI 17.8–84 vs. 33.1%, CI 9.4–70.2). The pooled prevalence of growth hormone deficiency (GHD) was 26.6% (95% CI 16–40.8). Conclusion: Our study revealed that near half of thalassemia patients suffer from growth impairments. However, regular evaluation of serum ferritin levels, close monitoring in a proper institute, suitable and acceptable treatment methods besides regular chelation therapy could significantly reduce the patients’ complications.
format	article
author	Morteza Arab-Zozani Setare Kheyrandish Amirhossein Rastgar Ebrahim Miri-Moghadam
author_facet	Morteza Arab-Zozani Setare Kheyrandish Amirhossein Rastgar Ebrahim Miri-Moghadam
author_sort	Morteza Arab-Zozani
title	A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
title_short	A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
title_full	A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
title_fullStr	A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
title_full_unstemmed	A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients
title_sort	systematic review and meta-analysis of stature growth complications in β-thalassemia major patients
publisher	Ubiquity Press
publishDate	2021
url	https://doaj.org/article/523e3822da984ffb9f001b722ccd1583
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A Systematic Review and Meta-Analysis of Stature Growth Complications in β-thalassemia Major Patients

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