Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.

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Autores principales:	Feimeng Zheng, Caifeng Yue, Guohui Li, Bin He, Wei Cheng, Xi Wang, Min Yan, Zijie Long, Wanshou Qiu, Zhongyu Yuan, Jie Xu, Bing Liu, Qian Shi, Eric W.-F. Lam, Mien-Chie Hung, Quentin Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/523eab01d43e4b06a01e642694020cbb
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spelling	oai:doaj.org-article:523eab01d43e4b06a01e642694020cbb2021-12-02T17:32:37ZNuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype10.1038/ncomms101802041-1723https://doaj.org/article/523eab01d43e4b06a01e642694020cbb2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10180https://doaj.org/toc/2041-1723Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.Feimeng ZhengCaifeng YueGuohui LiBin HeWei ChengXi WangMin YanZijie LongWanshou QiuZhongyu YuanJie XuBing LiuQian ShiEric W.-F. LamMien-Chie HungQuentin LiuNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feimeng Zheng Caifeng Yue Guohui Li Bin He Wei Cheng Xi Wang Min Yan Zijie Long Wanshou Qiu Zhongyu Yuan Jie Xu Bing Liu Qian Shi Eric W.-F. Lam Mien-Chie Hung Quentin Liu Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
description	Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.
format	article
author	Feimeng Zheng Caifeng Yue Guohui Li Bin He Wei Cheng Xi Wang Min Yan Zijie Long Wanshou Qiu Zhongyu Yuan Jie Xu Bing Liu Qian Shi Eric W.-F. Lam Mien-Chie Hung Quentin Liu
author_facet	Feimeng Zheng Caifeng Yue Guohui Li Bin He Wei Cheng Xi Wang Min Yan Zijie Long Wanshou Qiu Zhongyu Yuan Jie Xu Bing Liu Qian Shi Eric W.-F. Lam Mien-Chie Hung Quentin Liu
author_sort	Feimeng Zheng
title	Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
title_short	Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
title_full	Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
title_fullStr	Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
title_full_unstemmed	Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
title_sort	nuclear aurka acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/523eab01d43e4b06a01e642694020cbb
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Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

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