Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype

Aurora kinase A is a mitotic kinase that facilitates G2/M events. Here the authors show that in breast cancer cells Aurora kinase A has a kinase-independent function in the nucleus by activating the MYC promoter in cooperation with hnRNP K, enhancing the breast cancer stem cell phenotype.

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Detalles Bibliográficos
Autores principales: Feimeng Zheng, Caifeng Yue, Guohui Li, Bin He, Wei Cheng, Xi Wang, Min Yan, Zijie Long, Wanshou Qiu, Zhongyu Yuan, Jie Xu, Bing Liu, Qian Shi, Eric W.-F. Lam, Mien-Chie Hung, Quentin Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/523eab01d43e4b06a01e642694020cbb
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