INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS

Our aim was to study the effect of cycloferon on in vitro susceptibility of peripheral blood leukocytes to interferon-α2 in children with infectious mononucleosis in acute phase caused by Epstein-Barr virus (EBV). Materials and methods were as follows: the study included 23 children 4 to 6 years of...

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Autores principales:	L. M. Kurtasova, N. A. Shakina, A. R. Smidt, L. A. Ikkes
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	epstein–barr virus infectious mononucleosis leukocytes susceptibility interferon-alfa cycloferon Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/523ee452c86d408e9ded64d3f031d50e
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spelling	oai:doaj.org-article:523ee452c86d408e9ded64d3f031d50e2021-11-18T08:03:47ZINFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS1563-06252313-741X10.15789/1563-0625-2018-6-865-870https://doaj.org/article/523ee452c86d408e9ded64d3f031d50e2018-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1671https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XOur aim was to study the effect of cycloferon on in vitro susceptibility of peripheral blood leukocytes to interferon-α2 in children with infectious mononucleosis in acute phase caused by Epstein-Barr virus (EBV). Materials and methods were as follows: the study included 23 children 4 to 6 years of age admitted in acute period of infectious mononucleosis. The control group consisted of 15 healthy children of the same age group. In vitro susceptibility of peripheral blood leukocytes to interferon-α2 was determined by the method of L.M. Kurtasova (2007).Four types of in vitro response of peripheral blood leukocytes to interferon-α2 upon induction by cycloferon have been revealed in both healthy children and patients with EBV-positive infectious mononucleosis. Differences in occurrence rates of these 4 types of reactions have been found among patients with EBVinfection, in comparison with the group of healthy children. There was no regular dose-dependent changes in susceptibility of peripheral blood leukocytes to interferon-α2 in vitro after cycloferon induction in the group of children with EBV-infection. depending on the dose, which have been revealed in healthy children.L. M. KurtasovaN. A. ShakinaA. R. SmidtL. A. IkkesSPb RAACIarticleepstein–barr virusinfectious mononucleosisleukocytessusceptibilityinterferon-alfacycloferonImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 6, Pp 865-870 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	epstein–barr virus infectious mononucleosis leukocytes susceptibility interferon-alfa cycloferon Immunologic diseases. Allergy RC581-607
spellingShingle	epstein–barr virus infectious mononucleosis leukocytes susceptibility interferon-alfa cycloferon Immunologic diseases. Allergy RC581-607 L. M. Kurtasova N. A. Shakina A. R. Smidt L. A. Ikkes INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
description	Our aim was to study the effect of cycloferon on in vitro susceptibility of peripheral blood leukocytes to interferon-α2 in children with infectious mononucleosis in acute phase caused by Epstein-Barr virus (EBV). Materials and methods were as follows: the study included 23 children 4 to 6 years of age admitted in acute period of infectious mononucleosis. The control group consisted of 15 healthy children of the same age group. In vitro susceptibility of peripheral blood leukocytes to interferon-α2 was determined by the method of L.M. Kurtasova (2007).Four types of in vitro response of peripheral blood leukocytes to interferon-α2 upon induction by cycloferon have been revealed in both healthy children and patients with EBV-positive infectious mononucleosis. Differences in occurrence rates of these 4 types of reactions have been found among patients with EBVinfection, in comparison with the group of healthy children. There was no regular dose-dependent changes in susceptibility of peripheral blood leukocytes to interferon-α2 in vitro after cycloferon induction in the group of children with EBV-infection. depending on the dose, which have been revealed in healthy children.
format	article
author	L. M. Kurtasova N. A. Shakina A. R. Smidt L. A. Ikkes
author_facet	L. M. Kurtasova N. A. Shakina A. R. Smidt L. A. Ikkes
author_sort	L. M. Kurtasova
title	INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
title_short	INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
title_full	INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
title_fullStr	INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
title_full_unstemmed	INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS
title_sort	influence of cycloferon on the cellular susceptibility to interferon-α2 in vitro in patients with infectious mononucleosis caused by epstein– barr virus
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/523ee452c86d408e9ded64d3f031d50e
work_keys_str_mv	AT lmkurtasova influenceofcycloferononthecellularsusceptibilitytointerferona2invitroinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT nashakina influenceofcycloferononthecellularsusceptibilitytointerferona2invitroinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT arsmidt influenceofcycloferononthecellularsusceptibilitytointerferona2invitroinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus AT laikkes influenceofcycloferononthecellularsusceptibilitytointerferona2invitroinpatientswithinfectiousmononucleosiscausedbyepsteinbarrvirus
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INFLUENCE OF CYCLOFERON ON THE CELLULAR SUSCEPTIBILITY TO INTERFERON-α2 IN VITRO IN PATIENTS WITH INFECTIOUS MONONUCLEOSIS CAUSED BY EPSTEIN– BARR VIRUS

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