Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain a...
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Nature Portfolio
2017
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oai:doaj.org-article:524637c6ef354cce802fe1c89c4f312d2021-12-02T14:43:00ZContractile forces at tricellular contacts modulate epithelial organization and monolayer integrity10.1038/ncomms139982041-1723https://doaj.org/article/524637c6ef354cce802fe1c89c4f312d2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13998https://doaj.org/toc/2041-1723EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.Julie SalomonCécile GastonJérémy MagescasBoris DuvauchelleDanielle CanioniLucie SengmanivongAdeline MayeuxGrégoire MichauxFlorence CampeottoJulie LemaleJérôme VialaFrançoise PoirierNicolas MincJacques SchmitzNicole BrousseBenoit LadouxOlivier GouletDelphine DelacourNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017) |
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DOAJ |
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Science Q |
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Science Q Julie Salomon Cécile Gaston Jérémy Magescas Boris Duvauchelle Danielle Canioni Lucie Sengmanivong Adeline Mayeux Grégoire Michaux Florence Campeotto Julie Lemale Jérôme Viala Françoise Poirier Nicolas Minc Jacques Schmitz Nicole Brousse Benoit Ladoux Olivier Goulet Delphine Delacour Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
description |
EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement. |
format |
article |
author |
Julie Salomon Cécile Gaston Jérémy Magescas Boris Duvauchelle Danielle Canioni Lucie Sengmanivong Adeline Mayeux Grégoire Michaux Florence Campeotto Julie Lemale Jérôme Viala Françoise Poirier Nicolas Minc Jacques Schmitz Nicole Brousse Benoit Ladoux Olivier Goulet Delphine Delacour |
author_facet |
Julie Salomon Cécile Gaston Jérémy Magescas Boris Duvauchelle Danielle Canioni Lucie Sengmanivong Adeline Mayeux Grégoire Michaux Florence Campeotto Julie Lemale Jérôme Viala Françoise Poirier Nicolas Minc Jacques Schmitz Nicole Brousse Benoit Ladoux Olivier Goulet Delphine Delacour |
author_sort |
Julie Salomon |
title |
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
title_short |
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
title_full |
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
title_fullStr |
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
title_full_unstemmed |
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
title_sort |
contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/524637c6ef354cce802fe1c89c4f312d |
work_keys_str_mv |
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1718389566606409728 |