Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity

EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain a...

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Autores principales: Julie Salomon, Cécile Gaston, Jérémy Magescas, Boris Duvauchelle, Danielle Canioni, Lucie Sengmanivong, Adeline Mayeux, Grégoire Michaux, Florence Campeotto, Julie Lemale, Jérôme Viala, Françoise Poirier, Nicolas Minc, Jacques Schmitz, Nicole Brousse, Benoit Ladoux, Olivier Goulet, Delphine Delacour
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/524637c6ef354cce802fe1c89c4f312d
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spelling oai:doaj.org-article:524637c6ef354cce802fe1c89c4f312d2021-12-02T14:43:00ZContractile forces at tricellular contacts modulate epithelial organization and monolayer integrity10.1038/ncomms139982041-1723https://doaj.org/article/524637c6ef354cce802fe1c89c4f312d2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13998https://doaj.org/toc/2041-1723EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.Julie SalomonCécile GastonJérémy MagescasBoris DuvauchelleDanielle CanioniLucie SengmanivongAdeline MayeuxGrégoire MichauxFlorence CampeottoJulie LemaleJérôme VialaFrançoise PoirierNicolas MincJacques SchmitzNicole BrousseBenoit LadouxOlivier GouletDelphine DelacourNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julie Salomon
Cécile Gaston
Jérémy Magescas
Boris Duvauchelle
Danielle Canioni
Lucie Sengmanivong
Adeline Mayeux
Grégoire Michaux
Florence Campeotto
Julie Lemale
Jérôme Viala
Françoise Poirier
Nicolas Minc
Jacques Schmitz
Nicole Brousse
Benoit Ladoux
Olivier Goulet
Delphine Delacour
Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
description EpCAM is an unconventional epithelia-specific cell–cell adhesion molecule, that is mutated in the majority of cases of Congenital Tufting Enteropathy. Here the authors show that loss of EpCAM causes a concentration of contractile activity at tricellular junctions, leading to aberrant apical domain and tight junction displacement.
format article
author Julie Salomon
Cécile Gaston
Jérémy Magescas
Boris Duvauchelle
Danielle Canioni
Lucie Sengmanivong
Adeline Mayeux
Grégoire Michaux
Florence Campeotto
Julie Lemale
Jérôme Viala
Françoise Poirier
Nicolas Minc
Jacques Schmitz
Nicole Brousse
Benoit Ladoux
Olivier Goulet
Delphine Delacour
author_facet Julie Salomon
Cécile Gaston
Jérémy Magescas
Boris Duvauchelle
Danielle Canioni
Lucie Sengmanivong
Adeline Mayeux
Grégoire Michaux
Florence Campeotto
Julie Lemale
Jérôme Viala
Françoise Poirier
Nicolas Minc
Jacques Schmitz
Nicole Brousse
Benoit Ladoux
Olivier Goulet
Delphine Delacour
author_sort Julie Salomon
title Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
title_short Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
title_full Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
title_fullStr Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
title_full_unstemmed Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
title_sort contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/524637c6ef354cce802fe1c89c4f312d
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