Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures

Jemina Narvaez,1 Genessis Maldonado,1 Roberto Guerrero,1 Osvaldo Daniel Messina,2 Carlos Rios1 1Rheumatology Department, Espíritu Santo University, Guayaquil, Ecuador; 2Rheumatology Department, Hospital Cosme Argerich, Buenos Aires, ArgentinaCorrespondence: Genessis Maldonado Email genesi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Narvaez J, Maldonado G, Guerrero R, Messina OD, Rios C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	vitamin d supplementation falls bone mineral density. Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/5253221825ba4caba234420d458d2f02
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5253221825ba4caba234420d458d2f02
record_format	dspace
spelling	oai:doaj.org-article:5253221825ba4caba234420d458d2f022021-12-02T10:41:22ZVitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures1179-156Xhttps://doaj.org/article/5253221825ba4caba234420d458d2f022020-06-01T00:00:00Zhttps://www.dovepress.com/vitamin-d-megadose-definition-efficacy-in-bone-metabolism-risk-of-fall-peer-reviewed-article-OARRRhttps://doaj.org/toc/1179-156XJemina Narvaez,1 Genessis Maldonado,1 Roberto Guerrero,1 Osvaldo Daniel Messina,2 Carlos Rios1 1Rheumatology Department, Espíritu Santo University, Guayaquil, Ecuador; 2Rheumatology Department, Hospital Cosme Argerich, Buenos Aires, ArgentinaCorrespondence: Genessis Maldonado Email genesismaldonadovelez92@gmail.comIntroduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses. The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls.Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral density.Keywords: vitamin D, supplementation, falls, bone mineral densityNarvaez JMaldonado GGuerrero RMessina ODRios CDove Medical Pressarticlevitamin dsupplementationfallsbone mineral density.Diseases of the musculoskeletal systemRC925-935ENOpen Access Rheumatology: Research and Reviews, Vol Volume 12, Pp 105-115 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin d supplementation falls bone mineral density. Diseases of the musculoskeletal system RC925-935
spellingShingle	vitamin d supplementation falls bone mineral density. Diseases of the musculoskeletal system RC925-935 Narvaez J Maldonado G Guerrero R Messina OD Rios C Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
description	Jemina Narvaez,1 Genessis Maldonado,1 Roberto Guerrero,1 Osvaldo Daniel Messina,2 Carlos Rios1 1Rheumatology Department, Espíritu Santo University, Guayaquil, Ecuador; 2Rheumatology Department, Hospital Cosme Argerich, Buenos Aires, ArgentinaCorrespondence: Genessis Maldonado Email genesismaldonadovelez92@gmail.comIntroduction: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses. The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls.Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral density.Keywords: vitamin D, supplementation, falls, bone mineral density
format	article
author	Narvaez J Maldonado G Guerrero R Messina OD Rios C
author_facet	Narvaez J Maldonado G Guerrero R Messina OD Rios C
author_sort	Narvaez J
title	Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
title_short	Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
title_full	Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
title_fullStr	Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
title_full_unstemmed	Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures
title_sort	vitamin d megadose: definition, efficacy in bone metabolism, risk of falls and fractures
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/5253221825ba4caba234420d458d2f02
work_keys_str_mv	AT narvaezj vitamindmegadosedefinitionefficacyinbonemetabolismriskoffallsandfractures AT maldonadog vitamindmegadosedefinitionefficacyinbonemetabolismriskoffallsandfractures AT guerreror vitamindmegadosedefinitionefficacyinbonemetabolismriskoffallsandfractures AT messinaod vitamindmegadosedefinitionefficacyinbonemetabolismriskoffallsandfractures AT riosc vitamindmegadosedefinitionefficacyinbonemetabolismriskoffallsandfractures
_version_	1718396826283933696

Vitamin D Megadose: Definition, Efficacy in Bone Metabolism, Risk of Falls and Fractures

Ejemplares similares