Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on...

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Autores principales: Rutger C. C. Hengeveld, Martijn J. M. Vromans, Mathijs Vleugel, Michael A. Hadders, Susanne M. A. Lens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/52565a2b172f4948a7daae61f2125042
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spelling oai:doaj.org-article:52565a2b172f4948a7daae61f21250422021-12-02T14:41:07ZInner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing10.1038/ncomms155422041-1723https://doaj.org/article/52565a2b172f4948a7daae61f21250422017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15542https://doaj.org/toc/2041-1723Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.Rutger C. C. HengeveldMartijn J. M. VromansMathijs VleugelMichael A. HaddersSusanne M. A. LensNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Rutger C. C. Hengeveld
Martijn J. M. Vromans
Mathijs Vleugel
Michael A. Hadders
Susanne M. A. Lens
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
description Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.
format article
author Rutger C. C. Hengeveld
Martijn J. M. Vromans
Mathijs Vleugel
Michael A. Hadders
Susanne M. A. Lens
author_facet Rutger C. C. Hengeveld
Martijn J. M. Vromans
Mathijs Vleugel
Michael A. Hadders
Susanne M. A. Lens
author_sort Rutger C. C. Hengeveld
title Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
title_short Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
title_full Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
title_fullStr Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
title_full_unstemmed Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
title_sort inner centromere localization of the cpc maintains centromere cohesion and allows mitotic checkpoint silencing
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/52565a2b172f4948a7daae61f2125042
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