Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing
Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on...
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Nature Portfolio
2017
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oai:doaj.org-article:52565a2b172f4948a7daae61f21250422021-12-02T14:41:07ZInner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing10.1038/ncomms155422041-1723https://doaj.org/article/52565a2b172f4948a7daae61f21250422017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15542https://doaj.org/toc/2041-1723Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing.Rutger C. C. HengeveldMartijn J. M. VromansMathijs VleugelMichael A. HaddersSusanne M. A. LensNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017) |
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Science Q Rutger C. C. Hengeveld Martijn J. M. Vromans Mathijs Vleugel Michael A. Hadders Susanne M. A. Lens Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
description |
Precise chromosome segregation during mitosis requires coordination of stable chromosome bi-orientation with anaphase onset, however the underlying mechanism is not clear. Here the authors show that inner centromere localization of the chromosomal passenger complex maintains centromeric cohesion on bi-oriented chromosomes and allows mitotic checkpoint silencing. |
format |
article |
author |
Rutger C. C. Hengeveld Martijn J. M. Vromans Mathijs Vleugel Michael A. Hadders Susanne M. A. Lens |
author_facet |
Rutger C. C. Hengeveld Martijn J. M. Vromans Mathijs Vleugel Michael A. Hadders Susanne M. A. Lens |
author_sort |
Rutger C. C. Hengeveld |
title |
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
title_short |
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
title_full |
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
title_fullStr |
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
title_full_unstemmed |
Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing |
title_sort |
inner centromere localization of the cpc maintains centromere cohesion and allows mitotic checkpoint silencing |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/52565a2b172f4948a7daae61f2125042 |
work_keys_str_mv |
AT rutgercchengeveld innercentromerelocalizationofthecpcmaintainscentromerecohesionandallowsmitoticcheckpointsilencing AT martijnjmvromans innercentromerelocalizationofthecpcmaintainscentromerecohesionandallowsmitoticcheckpointsilencing AT mathijsvleugel innercentromerelocalizationofthecpcmaintainscentromerecohesionandallowsmitoticcheckpointsilencing AT michaelahadders innercentromerelocalizationofthecpcmaintainscentromerecohesionandallowsmitoticcheckpointsilencing AT susannemalens innercentromerelocalizationofthecpcmaintainscentromerecohesionandallowsmitoticcheckpointsilencing |
_version_ |
1718389988020715520 |