Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years. This review article focuses on how multidentate HOPOs can be used in targeted radiometal-based diagnostic an...

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Autores principales:	Xu Zhou, Linlin Dong, Langtao Shen
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hydroxypyridinone radiopharmaceutical gallium-68 zirconium-89 thorium-227 theranostic Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/5257472b630d47238f601423dcf7c34e
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spelling	oai:doaj.org-article:5257472b630d47238f601423dcf7c34e2021-11-25T18:29:00ZHydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals10.3390/molecules262269971420-3049https://doaj.org/article/5257472b630d47238f601423dcf7c34e2021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6997https://doaj.org/toc/1420-3049Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years. This review article focuses on how multidentate HOPOs can be used in targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals. The general structure of radiometal-based targeted radiopharmaceuticals, a brief description of siderophores, the basic structure and properties of bidentate HOPO, some representative HOPO multidentate chelating agents, radiopharmaceuticals based on HOPO multidentate bifunctional chelators for gallium-68, thorium-227 and zirconium-89, as well as the future prospects of HOPO multidentate bifunctional chelators in other metal-based radiopharmaceuticals are described and discussed in turn. The HOPO metal-based radiopharmaceuticals that have shown good prospects in clinical and preclinical studies are gallium-68, thorium-227 and zirconium-89 radiopharmaceuticals. We expect HOPO multidentate bifunctional chelators to be a very promising platform for building novel targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals.Xu ZhouLinlin DongLangtao ShenMDPI AGarticlehydroxypyridinoneradiopharmaceuticalgallium-68zirconium-89thorium-227theranosticOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6997, p 6997 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydroxypyridinone radiopharmaceutical gallium-68 zirconium-89 thorium-227 theranostic Organic chemistry QD241-441
spellingShingle	hydroxypyridinone radiopharmaceutical gallium-68 zirconium-89 thorium-227 theranostic Organic chemistry QD241-441 Xu Zhou Linlin Dong Langtao Shen Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
description	Hydroxypyridinones (HOPOs) have been used in the chelation therapy of iron and actinide metals. Their application in metal-based radiopharmaceuticals has also been increasing in recent years. This review article focuses on how multidentate HOPOs can be used in targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals. The general structure of radiometal-based targeted radiopharmaceuticals, a brief description of siderophores, the basic structure and properties of bidentate HOPO, some representative HOPO multidentate chelating agents, radiopharmaceuticals based on HOPO multidentate bifunctional chelators for gallium-68, thorium-227 and zirconium-89, as well as the future prospects of HOPO multidentate bifunctional chelators in other metal-based radiopharmaceuticals are described and discussed in turn. The HOPO metal-based radiopharmaceuticals that have shown good prospects in clinical and preclinical studies are gallium-68, thorium-227 and zirconium-89 radiopharmaceuticals. We expect HOPO multidentate bifunctional chelators to be a very promising platform for building novel targeted radiometal-based diagnostic and therapeutic radiopharmaceuticals.
format	article
author	Xu Zhou Linlin Dong Langtao Shen
author_facet	Xu Zhou Linlin Dong Langtao Shen
author_sort	Xu Zhou
title	Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
title_short	Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
title_full	Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
title_fullStr	Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
title_full_unstemmed	Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals
title_sort	hydroxypyridinones as a very promising platform for targeted diagnostic and therapeutic radiopharmaceuticals
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5257472b630d47238f601423dcf7c34e
work_keys_str_mv	AT xuzhou hydroxypyridinonesasaverypromisingplatformfortargeteddiagnosticandtherapeuticradiopharmaceuticals AT linlindong hydroxypyridinonesasaverypromisingplatformfortargeteddiagnosticandtherapeuticradiopharmaceuticals AT langtaoshen hydroxypyridinonesasaverypromisingplatformfortargeteddiagnosticandtherapeuticradiopharmaceuticals
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Hydroxypyridinones as a Very Promising Platform for Targeted Diagnostic and Therapeutic Radiopharmaceuticals

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