Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells

Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML-initiating cells via interplay between stromal and T...

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Autores principales:	Yan Xu, Satoshi Ikeda, Kentaro Sumida, Ryusuke Yamamoto, Hiroki Tanaka, Nagahiro Minato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5257dd023ec6425cad3f0923e8fae487
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spelling	oai:doaj.org-article:5257dd023ec6425cad3f0923e8fae4872021-12-02T15:34:19ZSipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells10.1038/s41467-018-03307-82041-1723https://doaj.org/article/5257dd023ec6425cad3f0923e8fae4872018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03307-8https://doaj.org/toc/2041-1723Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML-initiating cells via interplay between stromal and T cells.Yan XuSatoshi IkedaKentaro SumidaRyusuke YamamotoHiroki TanakaNagahiro MinatoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yan Xu Satoshi Ikeda Kentaro Sumida Ryusuke Yamamoto Hiroki Tanaka Nagahiro Minato Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
description	Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML-initiating cells via interplay between stromal and T cells.
format	article
author	Yan Xu Satoshi Ikeda Kentaro Sumida Ryusuke Yamamoto Hiroki Tanaka Nagahiro Minato
author_facet	Yan Xu Satoshi Ikeda Kentaro Sumida Ryusuke Yamamoto Hiroki Tanaka Nagahiro Minato
author_sort	Yan Xu
title	Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
title_short	Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
title_full	Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
title_fullStr	Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
title_full_unstemmed	Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
title_sort	sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5257dd023ec6425cad3f0923e8fae487
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Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells

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