Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes
Abstract Fatty-acid-binding proteins (FABPs) are small intracellular proteins that coordinate lipid-mediated processes by targeting metabolic and immune response pathways. The aim of the study was to investigate plasma FABPs levels and their relationship with clinical outcomes in cirrhosis. Plasma l...
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Nature Portfolio
2017
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oai:doaj.org-article:525a30fc94354712b2baef14a0ab72592021-12-02T12:32:12ZAdipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes10.1038/s41598-017-01709-02045-2322https://doaj.org/article/525a30fc94354712b2baef14a0ab72592017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01709-0https://doaj.org/toc/2045-2322Abstract Fatty-acid-binding proteins (FABPs) are small intracellular proteins that coordinate lipid-mediated processes by targeting metabolic and immune response pathways. The aim of the study was to investigate plasma FABPs levels and their relationship with clinical outcomes in cirrhosis. Plasma levels of L-FABP1(liver and kidney), I-FABP2(intestine), and A-FABP4(adipocyte and macrophages) were measured in 274 patients with decompensated cirrhosis. Hepatic gene expression of FABPs was assessed in liver biopsies from patients with decompensated cirrhosis and in liver cell types from mice with cirrhosis. Immunohistochemistry of A-FABP4 in human liver biopsy was also performed. Plasma levels of FABPs were increased in patients with decompensated cirrhosis compared to those of healthy subjects (L-FABP1: 25 (17–39) vs 10 (9–17) ng/mL p = 0.001, I-FABP2: 1.1 (0.5–2.1) vs 0.6 (0.4–1) ng/mL p = 0.04 and A-FABP4: 37 (20–68) vs 16 (11–33) ng/mL p = 0.002), respectively. Increased A-FABP4 levels were associated with complications of cirrhosis, acute-on-chronic liver failure and poor survival. Hepatic A-FABP4 gene expression was upregulated in decompensated cirrhosis. Macrophages were the main liver cell that over-expressed A-FABP4 in experimental cirrhosis and increased A-FABP4 was found in macrophages of human biopsies by immunohistochemistry. A-FABP4 levels are increased in decompensated cirrhosis and correlate with poor outcomes. Liver macrophages appear to be the main source of A-FABP4 in decompensated cirrhosis.Isabel GrauperaMar CollElisa PoseChiara EliaSalvatore PianoElsa SolàDelia BlayaPatricia HuelinCristina SoléRebeca MoreiraGloria de PradaNúria FabrellasAdrià JuanolaManuel Morales-RuizPau Sancho-BruCàndid VillanuevaPere GinèsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) |
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DOAJ |
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DOAJ |
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Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Isabel Graupera Mar Coll Elisa Pose Chiara Elia Salvatore Piano Elsa Solà Delia Blaya Patricia Huelin Cristina Solé Rebeca Moreira Gloria de Prada Núria Fabrellas Adrià Juanola Manuel Morales-Ruiz Pau Sancho-Bru Càndid Villanueva Pere Ginès Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| description |
Abstract Fatty-acid-binding proteins (FABPs) are small intracellular proteins that coordinate lipid-mediated processes by targeting metabolic and immune response pathways. The aim of the study was to investigate plasma FABPs levels and their relationship with clinical outcomes in cirrhosis. Plasma levels of L-FABP1(liver and kidney), I-FABP2(intestine), and A-FABP4(adipocyte and macrophages) were measured in 274 patients with decompensated cirrhosis. Hepatic gene expression of FABPs was assessed in liver biopsies from patients with decompensated cirrhosis and in liver cell types from mice with cirrhosis. Immunohistochemistry of A-FABP4 in human liver biopsy was also performed. Plasma levels of FABPs were increased in patients with decompensated cirrhosis compared to those of healthy subjects (L-FABP1: 25 (17–39) vs 10 (9–17) ng/mL p = 0.001, I-FABP2: 1.1 (0.5–2.1) vs 0.6 (0.4–1) ng/mL p = 0.04 and A-FABP4: 37 (20–68) vs 16 (11–33) ng/mL p = 0.002), respectively. Increased A-FABP4 levels were associated with complications of cirrhosis, acute-on-chronic liver failure and poor survival. Hepatic A-FABP4 gene expression was upregulated in decompensated cirrhosis. Macrophages were the main liver cell that over-expressed A-FABP4 in experimental cirrhosis and increased A-FABP4 was found in macrophages of human biopsies by immunohistochemistry. A-FABP4 levels are increased in decompensated cirrhosis and correlate with poor outcomes. Liver macrophages appear to be the main source of A-FABP4 in decompensated cirrhosis. |
| format |
article |
| author |
Isabel Graupera Mar Coll Elisa Pose Chiara Elia Salvatore Piano Elsa Solà Delia Blaya Patricia Huelin Cristina Solé Rebeca Moreira Gloria de Prada Núria Fabrellas Adrià Juanola Manuel Morales-Ruiz Pau Sancho-Bru Càndid Villanueva Pere Ginès |
| author_facet |
Isabel Graupera Mar Coll Elisa Pose Chiara Elia Salvatore Piano Elsa Solà Delia Blaya Patricia Huelin Cristina Solé Rebeca Moreira Gloria de Prada Núria Fabrellas Adrià Juanola Manuel Morales-Ruiz Pau Sancho-Bru Càndid Villanueva Pere Ginès |
| author_sort |
Isabel Graupera |
| title |
Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| title_short |
Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| title_full |
Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| title_fullStr |
Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| title_full_unstemmed |
Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes |
| title_sort |
adipocyte fatty-acid binding protein is overexpressed in cirrhosis and correlates with clinical outcomes |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/525a30fc94354712b2baef14a0ab7259 |
| work_keys_str_mv |
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