Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

The invasion of epithelial tumours often depends on the epithelial-mesenchymal transition. Here, the authors report that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1.

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Autores principales:	Caterina Miro, Emery Di Cicco, Raffaele Ambrosio, Giuseppina Mancino, Daniela Di Girolamo, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Annarita Nappi, Maria Angela De Stefano, Cristina Luongo, Dario Antonini, Feliciano Visconte, Silvia Varricchio, Gennaro Ilardi, Luigi Del Vecchio, Stefania Staibano, Anita Boelen, Cedric Blanpain, Caterina Missero, Domenico Salvatore, Monica Dentice
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/525c7f8d0b1d4074aa8b48a33be11c22
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spelling	oai:doaj.org-article:525c7f8d0b1d4074aa8b48a33be11c222021-12-02T14:40:19ZThyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch10.1038/s41467-019-13140-22041-1723https://doaj.org/article/525c7f8d0b1d4074aa8b48a33be11c222019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13140-2https://doaj.org/toc/2041-1723The invasion of epithelial tumours often depends on the epithelial-mesenchymal transition. Here, the authors report that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1.Caterina MiroEmery Di CiccoRaffaele AmbrosioGiuseppina MancinoDaniela Di GirolamoAnnunziata Gaetana CicatielloSerena SagliocchiAnnarita NappiMaria Angela De StefanoCristina LuongoDario AntoniniFeliciano VisconteSilvia VarricchioGennaro IlardiLuigi Del VecchioStefania StaibanoAnita BoelenCedric BlanpainCaterina MisseroDomenico SalvatoreMonica DenticeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caterina Miro Emery Di Cicco Raffaele Ambrosio Giuseppina Mancino Daniela Di Girolamo Annunziata Gaetana Cicatiello Serena Sagliocchi Annarita Nappi Maria Angela De Stefano Cristina Luongo Dario Antonini Feliciano Visconte Silvia Varricchio Gennaro Ilardi Luigi Del Vecchio Stefania Staibano Anita Boelen Cedric Blanpain Caterina Missero Domenico Salvatore Monica Dentice Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
description	The invasion of epithelial tumours often depends on the epithelial-mesenchymal transition. Here, the authors report that intracellular activation of thyroid hormone by the D2 deiodinase enzyme promotes invasion and progression of squamous cell carcinoma by transcriptionally up-regulating ZEB-1.
format	article
author	Caterina Miro Emery Di Cicco Raffaele Ambrosio Giuseppina Mancino Daniela Di Girolamo Annunziata Gaetana Cicatiello Serena Sagliocchi Annarita Nappi Maria Angela De Stefano Cristina Luongo Dario Antonini Feliciano Visconte Silvia Varricchio Gennaro Ilardi Luigi Del Vecchio Stefania Staibano Anita Boelen Cedric Blanpain Caterina Missero Domenico Salvatore Monica Dentice
author_facet	Caterina Miro Emery Di Cicco Raffaele Ambrosio Giuseppina Mancino Daniela Di Girolamo Annunziata Gaetana Cicatiello Serena Sagliocchi Annarita Nappi Maria Angela De Stefano Cristina Luongo Dario Antonini Feliciano Visconte Silvia Varricchio Gennaro Ilardi Luigi Del Vecchio Stefania Staibano Anita Boelen Cedric Blanpain Caterina Missero Domenico Salvatore Monica Dentice
author_sort	Caterina Miro
title	Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
title_short	Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
title_full	Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
title_fullStr	Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
title_full_unstemmed	Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch
title_sort	thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a zeb-1/e-cadherin switch
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/525c7f8d0b1d4074aa8b48a33be11c22
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Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch

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