Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.

<h4>Background</h4>In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated with abnormal ventilation distribution. The primary objective of this analysis was to determine the relationships between ventilation distribution outcomes an...

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Autores principales: Graham L Hall, Karla M Logie, Faith Parsons, Sven M Schulzke, Gary Nolan, Conor Murray, Sarath Ranganathan, Phil Robinson, Peter D Sly, Stephen M Stick, AREST CF, Luke Berry, Luke Garratt, John Massie, Lauren Mott, Srinivas Poreddy, Shannon Simpson
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Publicado: Public Library of Science (PLoS) 2011
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spelling oai:doaj.org-article:52615d43f9594865b2b1f67eb64f00492021-11-18T06:47:34ZAir trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.1932-620310.1371/journal.pone.0023932https://doaj.org/article/52615d43f9594865b2b1f67eb64f00492011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21886842/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated with abnormal ventilation distribution. The primary objective of this analysis was to determine the relationships between ventilation distribution outcomes and the presence and extent of structural damage as assessed by chest CT in infants and young children with CF.<h4>Methods</h4>Data of infants and young children with CF diagnosed following newborn screening consecutively reviewed between August 2005 and December 2009 were analysed. Ventilation distribution (lung clearance index and the first and second moment ratios [LCI, M(1)/M(0) and M(2)/M(0), respectively]), chest CT and airway pathology from bronchoalveolar lavage were determined at diagnosis and then annually. The chest CT scans were evaluated for the presence or absence of bronchiectasis and air trapping.<h4>Results</h4>Matched lung function, chest CT and pathology outcomes were available in 49 infants (31 male) with bronchiectasis and air trapping present in 13 (27%) and 24 (49%) infants, respectively. The presence of bronchiectasis or air trapping was associated with increased M(2)/M(0) but not LCI or M(1)/M(0). There was a weak, but statistically significant association between the extent of air trapping and all ventilation distribution outcomes.<h4>Conclusion</h4>These findings suggest that in early CF lung disease there are weak associations between ventilation distribution and lung damage from chest CT. These finding are in contrast to those reported in older children. These findings suggest that assessments of LCI could not be used to replace a chest CT scan for the assessment of structural lung disease in the first two years of life. Further research in which both MBW and chest CT outcomes are obtained is required to assess the role of ventilation distribution in tracking the progression of lung damage in infants with CF.Graham L HallKarla M LogieFaith ParsonsSven M SchulzkeGary NolanConor MurraySarath RanganathanPhil RobinsonPeter D SlyStephen M StickAREST CFLuke BerryLuke GarrattJohn MassieLauren MottSrinivas PoreddyShannon SimpsonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23932 (2011)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Graham L Hall
Karla M Logie
Faith Parsons
Sven M Schulzke
Gary Nolan
Conor Murray
Sarath Ranganathan
Phil Robinson
Peter D Sly
Stephen M Stick
AREST CF
Luke Berry
Luke Garratt
John Massie
Lauren Mott
Srinivas Poreddy
Shannon Simpson
Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
description <h4>Background</h4>In school-aged children with cystic fibrosis (CF) structural lung damage assessed using chest CT is associated with abnormal ventilation distribution. The primary objective of this analysis was to determine the relationships between ventilation distribution outcomes and the presence and extent of structural damage as assessed by chest CT in infants and young children with CF.<h4>Methods</h4>Data of infants and young children with CF diagnosed following newborn screening consecutively reviewed between August 2005 and December 2009 were analysed. Ventilation distribution (lung clearance index and the first and second moment ratios [LCI, M(1)/M(0) and M(2)/M(0), respectively]), chest CT and airway pathology from bronchoalveolar lavage were determined at diagnosis and then annually. The chest CT scans were evaluated for the presence or absence of bronchiectasis and air trapping.<h4>Results</h4>Matched lung function, chest CT and pathology outcomes were available in 49 infants (31 male) with bronchiectasis and air trapping present in 13 (27%) and 24 (49%) infants, respectively. The presence of bronchiectasis or air trapping was associated with increased M(2)/M(0) but not LCI or M(1)/M(0). There was a weak, but statistically significant association between the extent of air trapping and all ventilation distribution outcomes.<h4>Conclusion</h4>These findings suggest that in early CF lung disease there are weak associations between ventilation distribution and lung damage from chest CT. These finding are in contrast to those reported in older children. These findings suggest that assessments of LCI could not be used to replace a chest CT scan for the assessment of structural lung disease in the first two years of life. Further research in which both MBW and chest CT outcomes are obtained is required to assess the role of ventilation distribution in tracking the progression of lung damage in infants with CF.
format article
author Graham L Hall
Karla M Logie
Faith Parsons
Sven M Schulzke
Gary Nolan
Conor Murray
Sarath Ranganathan
Phil Robinson
Peter D Sly
Stephen M Stick
AREST CF
Luke Berry
Luke Garratt
John Massie
Lauren Mott
Srinivas Poreddy
Shannon Simpson
author_facet Graham L Hall
Karla M Logie
Faith Parsons
Sven M Schulzke
Gary Nolan
Conor Murray
Sarath Ranganathan
Phil Robinson
Peter D Sly
Stephen M Stick
AREST CF
Luke Berry
Luke Garratt
John Massie
Lauren Mott
Srinivas Poreddy
Shannon Simpson
author_sort Graham L Hall
title Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
title_short Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
title_full Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
title_fullStr Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
title_full_unstemmed Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
title_sort air trapping on chest ct is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening.
publisher Public Library of Science (PLoS)
publishDate 2011
url https://doaj.org/article/52615d43f9594865b2b1f67eb64f0049
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