Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that terminally expose N-acetyl-neuraminic acid (sialic acid, Neu5...

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Autores principales:	Zoe Virion, Stéphane Doly, Kusumika Saha, Mireille Lambert, François Guillonneau, Camille Bied, Rebecca M. Duke, Pauline M. Rudd, Catherine Robbe-Masselot, Xavier Nassif, Mathieu Coureuil, Stefano Marullo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c
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spelling	oai:doaj.org-article:5266fe5b61d4428e97255621e2d00f9c2021-12-02T14:38:57ZSialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili10.1038/s41467-019-12685-62041-1723https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c2019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12685-6https://doaj.org/toc/2041-1723Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that terminally expose N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues.Zoe VirionStéphane DolyKusumika SahaMireille LambertFrançois GuillonneauCamille BiedRebecca M. DukePauline M. RuddCatherine Robbe-MasselotXavier NassifMathieu CoureuilStefano MarulloNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zoe Virion Stéphane Doly Kusumika Saha Mireille Lambert François Guillonneau Camille Bied Rebecca M. Duke Pauline M. Rudd Catherine Robbe-Masselot Xavier Nassif Mathieu Coureuil Stefano Marullo Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
description	Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that terminally expose N-acetyl-neuraminic acid (sialic acid, Neu5Ac) residues.
format	article
author	Zoe Virion Stéphane Doly Kusumika Saha Mireille Lambert François Guillonneau Camille Bied Rebecca M. Duke Pauline M. Rudd Catherine Robbe-Masselot Xavier Nassif Mathieu Coureuil Stefano Marullo
author_facet	Zoe Virion Stéphane Doly Kusumika Saha Mireille Lambert François Guillonneau Camille Bied Rebecca M. Duke Pauline M. Rudd Catherine Robbe-Masselot Xavier Nassif Mathieu Coureuil Stefano Marullo
author_sort	Zoe Virion
title	Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
title_short	Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
title_full	Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
title_fullStr	Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
title_full_unstemmed	Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
title_sort	sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c
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Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili

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