Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili

Sialic acid mediated mechanical activation of β2 adrenergic receptors by bacterial pili

Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that terminally expose N-acetyl-neuraminic acid (sialic acid, Neu5...

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Main Authors: Zoe Virion, Stéphane Doly, Kusumika Saha, Mireille Lambert, François Guillonneau, Camille Bied, Rebecca M. Duke, Pauline M. Rudd, Catherine Robbe-Masselot, Xavier Nassif, Mathieu Coureuil, Stefano Marullo
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c
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