Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

Trabjerg et al. show that the activity of carnitine palmitoyl transferase 1 (CPT1) and lipid metabolism are associated with the disease progression of the SOD1 G93A mouse model mimicking a motor neuron disease Amyotrophic lateral sclerosis (ALS). This study suggests CPT1 as a potential therapeutic t...

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Autores principales:	Michael Sloth Trabjerg, Dennis Christian Andersen, Pam Huntjens, Kirsten Egelund Oklinski, Luise Bolther, Jonas Laugård Hald, Amalie Elton Baisgaard, Kasper Mørk, Nikolaj Warming, Ulla Bismark Kullab, Lona John Kroese, Colin Eliot Jason Pritchard, Ivo Johan Huijbers, John Dirk Vestergaard Nieland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5269810b80934c57ac33e8b9c0b83b68
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spelling	oai:doaj.org-article:5269810b80934c57ac33e8b9c0b83b682021-12-02T16:55:45ZDownregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS10.1038/s42003-021-02034-z2399-3642https://doaj.org/article/5269810b80934c57ac33e8b9c0b83b682021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02034-zhttps://doaj.org/toc/2399-3642Trabjerg et al. show that the activity of carnitine palmitoyl transferase 1 (CPT1) and lipid metabolism are associated with the disease progression of the SOD1 G93A mouse model mimicking a motor neuron disease Amyotrophic lateral sclerosis (ALS). This study suggests CPT1 as a potential therapeutic target in treating ALS.Michael Sloth TrabjergDennis Christian AndersenPam HuntjensKirsten Egelund OklinskiLuise BoltherJonas Laugård HaldAmalie Elton BaisgaardKasper MørkNikolaj WarmingUlla Bismark KullabLona John KroeseColin Eliot Jason PritchardIvo Johan HuijbersJohn Dirk Vestergaard NielandNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Michael Sloth Trabjerg Dennis Christian Andersen Pam Huntjens Kirsten Egelund Oklinski Luise Bolther Jonas Laugård Hald Amalie Elton Baisgaard Kasper Mørk Nikolaj Warming Ulla Bismark Kullab Lona John Kroese Colin Eliot Jason Pritchard Ivo Johan Huijbers John Dirk Vestergaard Nieland Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
description	Trabjerg et al. show that the activity of carnitine palmitoyl transferase 1 (CPT1) and lipid metabolism are associated with the disease progression of the SOD1 G93A mouse model mimicking a motor neuron disease Amyotrophic lateral sclerosis (ALS). This study suggests CPT1 as a potential therapeutic target in treating ALS.
format	article
author	Michael Sloth Trabjerg Dennis Christian Andersen Pam Huntjens Kirsten Egelund Oklinski Luise Bolther Jonas Laugård Hald Amalie Elton Baisgaard Kasper Mørk Nikolaj Warming Ulla Bismark Kullab Lona John Kroese Colin Eliot Jason Pritchard Ivo Johan Huijbers John Dirk Vestergaard Nieland
author_facet	Michael Sloth Trabjerg Dennis Christian Andersen Pam Huntjens Kirsten Egelund Oklinski Luise Bolther Jonas Laugård Hald Amalie Elton Baisgaard Kasper Mørk Nikolaj Warming Ulla Bismark Kullab Lona John Kroese Colin Eliot Jason Pritchard Ivo Johan Huijbers John Dirk Vestergaard Nieland
author_sort	Michael Sloth Trabjerg
title	Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
title_short	Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
title_full	Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
title_fullStr	Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
title_full_unstemmed	Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS
title_sort	downregulating carnitine palmitoyl transferase 1 affects disease progression in the sod1 g93a mouse model of als
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5269810b80934c57ac33e8b9c0b83b68
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Downregulating carnitine palmitoyl transferase 1 affects disease progression in the SOD1 G93A mouse model of ALS

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