Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.

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Autores principales:	Thergiory Irrazabal, Bhupesh K. Thakur, Mingsong Kang, Yann Malaise, Catherine Streutker, Erin O. Y. Wong, Julia Copeland, Robert Gryfe, David S. Guttman, William W. Navarre, Alberto Martin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e5
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spelling	oai:doaj.org-article:526a67a99acf4d7686fe026f8f5cd7e52021-12-02T14:42:29ZLimiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer10.1038/s41467-020-15549-62041-1723https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15549-6https://doaj.org/toc/2041-1723It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.Thergiory IrrazabalBhupesh K. ThakurMingsong KangYann MalaiseCatherine StreutkerErin O. Y. WongJulia CopelandRobert GryfeDavid S. GuttmanWilliam W. NavarreAlberto MartinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thergiory Irrazabal Bhupesh K. Thakur Mingsong Kang Yann Malaise Catherine Streutker Erin O. Y. Wong Julia Copeland Robert Gryfe David S. Guttman William W. Navarre Alberto Martin Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
description	It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.
format	article
author	Thergiory Irrazabal Bhupesh K. Thakur Mingsong Kang Yann Malaise Catherine Streutker Erin O. Y. Wong Julia Copeland Robert Gryfe David S. Guttman William W. Navarre Alberto Martin
author_facet	Thergiory Irrazabal Bhupesh K. Thakur Mingsong Kang Yann Malaise Catherine Streutker Erin O. Y. Wong Julia Copeland Robert Gryfe David S. Guttman William W. Navarre Alberto Martin
author_sort	Thergiory Irrazabal
title	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
title_short	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
title_full	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
title_fullStr	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
title_full_unstemmed	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer
title_sort	limiting oxidative dna damage reduces microbe-induced colitis-associated colorectal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e5
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Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

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