Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer

It is unclear how microbial-induced inflammation promotes neoplastic transformation in colitis-associated cancer (CAC). Here, the authors use models of CAC to show that inflammation induces 8-oxoguanine lesions in DNA, and that antioxidants can reduce these DNA lesions as well as CAC.

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Detalles Bibliográficos
Autores principales: Thergiory Irrazabal, Bhupesh K. Thakur, Mingsong Kang, Yann Malaise, Catherine Streutker, Erin O. Y. Wong, Julia Copeland, Robert Gryfe, David S. Guttman, William W. Navarre, Alberto Martin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/526a67a99acf4d7686fe026f8f5cd7e5
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