Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.

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Autores principales:	Xing Xiao, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, André Kleinridders, Donald A. Morgan, F. Thomas Wunderlich, Kamal Rahmouni, Dong Kong, Thomas E. Scammell, Bradford B. Lowell, Peter Kloppenburg, Jens C. Brüning, A. Christine Hausen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
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spelling	oai:doaj.org-article:526ad1da292b4e9a9a66f3e0635380a62021-12-02T19:10:44ZOrexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity10.1038/s41467-021-25380-22041-1723https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a62021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25380-2https://doaj.org/toc/2041-1723The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.Xing XiaoGagik YeghiazaryanSimon HessPaul KlemmAnna SiebenAndré KleinriddersDonald A. MorganF. Thomas WunderlichKamal RahmouniDong KongThomas E. ScammellBradford B. LowellPeter KloppenburgJens C. BrüningA. Christine HausenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xing Xiao Gagik Yeghiazaryan Simon Hess Paul Klemm Anna Sieben André Kleinridders Donald A. Morgan F. Thomas Wunderlich Kamal Rahmouni Dong Kong Thomas E. Scammell Bradford B. Lowell Peter Kloppenburg Jens C. Brüning A. Christine Hausen Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
description	The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.
format	article
author	Xing Xiao Gagik Yeghiazaryan Simon Hess Paul Klemm Anna Sieben André Kleinridders Donald A. Morgan F. Thomas Wunderlich Kamal Rahmouni Dong Kong Thomas E. Scammell Bradford B. Lowell Peter Kloppenburg Jens C. Brüning A. Christine Hausen
author_facet	Xing Xiao Gagik Yeghiazaryan Simon Hess Paul Klemm Anna Sieben André Kleinridders Donald A. Morgan F. Thomas Wunderlich Kamal Rahmouni Dong Kong Thomas E. Scammell Bradford B. Lowell Peter Kloppenburg Jens C. Brüning A. Christine Hausen
author_sort	Xing Xiao
title	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
title_short	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
title_full	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
title_fullStr	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
title_full_unstemmed	Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
title_sort	orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
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Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

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