Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

Orexin receptors 1 and 2 in serotonergic neurons differentially regulate peripheral glucose metabolism in obesity

The wake-active orexin system plays a central role in the dynamic regulation of glucose homeostasis. Here the authors report that inactivation of the orexin receptor type 1 or 2 in serotonergic neurons differentially regulate systemic glucose homeostasis in the context of diet induced obesity.

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Bibliographic Details
Main Authors: Xing Xiao, Gagik Yeghiazaryan, Simon Hess, Paul Klemm, Anna Sieben, André Kleinridders, Donald A. Morgan, F. Thomas Wunderlich, Kamal Rahmouni, Dong Kong, Thomas E. Scammell, Bradford B. Lowell, Peter Kloppenburg, Jens C. Brüning, A. Christine Hausen
Format: article
Language:EN
Published: Nature Portfolio 2021
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Science
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Online Access:https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6
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https://doaj.org/article/526ad1da292b4e9a9a66f3e0635380a6

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