COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL

Objective: To compare efficacy of micronized per rectal progesterone (cyclogest pessary) and placebo in prevention of preterm birth in tertiary care hospital. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Study was conducted at department of gynecology and Obst...

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Autores principales:	Nighat Afridi, Ambreen Fatima, Amna Fareed, Saifullah Khan, Shah Gul Khan
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	progesterone preterm birth cyclogest pessary. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/526bd96b5a2e4fa283a9ba57d471e384
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spelling	oai:doaj.org-article:526bd96b5a2e4fa283a9ba57d471e3842021-12-02T19:12:10ZCOMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITALdoi.org/10.51253/pafmj.v70i6.24500030-96482411-8842https://doaj.org/article/526bd96b5a2e4fa283a9ba57d471e3842020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2450https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare efficacy of micronized per rectal progesterone (cyclogest pessary) and placebo in prevention of preterm birth in tertiary care hospital. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Study was conducted at department of gynecology and Obstetrics, Combined Military Hospital Nowshera, Khyber Pakhtunkhwa, from Jan 2018 to Jun 2018. Methodology: A sample size of 140 patients was calculated using WHO calculator. Non probability consecutive sampling was used for recruitment of participants. Ethics approval and consent forms were taken. Women were divided into two groups randomly. Group A was given micronized progesterone (cyclogest pessary) per rectal usage and group B was given placebo. Patients were followed for maternal and neonatal outcomes. Data was analyzed using SPSS version 23. Independent t-test was applied. p-value ≤0.05 was considered significant. Results: Total 140 patients were included in study. Mean age of women was 29.4 years ± 4.6SD. Patients in micronized progesterone (cyclogest pessary) was more effective in increasing birth weight (p=0.00), Apgar score maintenance at 1st (p=0.00) and 5th minute (p=0.000) and reduction in length of hospital stay (p=0.000) as compared to placebo. Patients were more satisfied with micronized progesterone (cyclogest pessary) per rectal as compared to placebo (p=0.00). Conclusion: Preterm birth is remained as significant issue in health care system of Pakistan. However, micronized progesterone (cyclogest pessary) per rectal usage had positive impact in improving maternal and neonatal health outcomes. Effective strategies for prevention of preterm birth in Pakistan are required.Nighat AfridiAmbreen FatimaAmna FareedSaifullah KhanShah Gul KhanArmy Medical College Rawalpindiarticleprogesteronepreterm birthcyclogest pessary.MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1859-1863 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	progesterone preterm birth cyclogest pessary. Medicine R Medicine (General) R5-920
spellingShingle	progesterone preterm birth cyclogest pessary. Medicine R Medicine (General) R5-920 Nighat Afridi Ambreen Fatima Amna Fareed Saifullah Khan Shah Gul Khan COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
description	Objective: To compare efficacy of micronized per rectal progesterone (cyclogest pessary) and placebo in prevention of preterm birth in tertiary care hospital. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Study was conducted at department of gynecology and Obstetrics, Combined Military Hospital Nowshera, Khyber Pakhtunkhwa, from Jan 2018 to Jun 2018. Methodology: A sample size of 140 patients was calculated using WHO calculator. Non probability consecutive sampling was used for recruitment of participants. Ethics approval and consent forms were taken. Women were divided into two groups randomly. Group A was given micronized progesterone (cyclogest pessary) per rectal usage and group B was given placebo. Patients were followed for maternal and neonatal outcomes. Data was analyzed using SPSS version 23. Independent t-test was applied. p-value ≤0.05 was considered significant. Results: Total 140 patients were included in study. Mean age of women was 29.4 years ± 4.6SD. Patients in micronized progesterone (cyclogest pessary) was more effective in increasing birth weight (p=0.00), Apgar score maintenance at 1st (p=0.00) and 5th minute (p=0.000) and reduction in length of hospital stay (p=0.000) as compared to placebo. Patients were more satisfied with micronized progesterone (cyclogest pessary) per rectal as compared to placebo (p=0.00). Conclusion: Preterm birth is remained as significant issue in health care system of Pakistan. However, micronized progesterone (cyclogest pessary) per rectal usage had positive impact in improving maternal and neonatal health outcomes. Effective strategies for prevention of preterm birth in Pakistan are required.
format	article
author	Nighat Afridi Ambreen Fatima Amna Fareed Saifullah Khan Shah Gul Khan
author_facet	Nighat Afridi Ambreen Fatima Amna Fareed Saifullah Khan Shah Gul Khan
author_sort	Nighat Afridi
title	COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
title_short	COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
title_full	COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
title_fullStr	COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
title_full_unstemmed	COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL
title_sort	comparison of micronized progesterone (cyclogest pessary) and placebo in prevention of pre-term birth in tertiary care hospital
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/526bd96b5a2e4fa283a9ba57d471e384
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COMPARISON OF MICRONIZED PROGESTERONE (CYCLOGEST PESSARY) AND PLACEBO IN PREVENTION OF PRE-TERM BIRTH IN TERTIARY CARE HOSPITAL

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