Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels
Orai channels belong to the calcium release-activated calcium (CRAC) channel family. Orai channels are responsible for the influx of extracellular Ca<sup>2+</sup> that is triggered by Ca<sup>2+</sup> depletion from the endoplasmic reticulum (ER); this function is essential fo...
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MDPI AG
2021
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oai:doaj.org-article:5271a58d50704360b9a22cad80179e2b2021-11-25T17:11:00ZStructural Insights into Ca<sup>2+</sup> Permeation through Orai Channels10.3390/cells101130622073-4409https://doaj.org/article/5271a58d50704360b9a22cad80179e2b2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3062https://doaj.org/toc/2073-4409Orai channels belong to the calcium release-activated calcium (CRAC) channel family. Orai channels are responsible for the influx of extracellular Ca<sup>2+</sup> that is triggered by Ca<sup>2+</sup> depletion from the endoplasmic reticulum (ER); this function is essential for many types of non-excitable cells. Extensive structural and functional studies have advanced the knowledge of the molecular mechanism by which Orai channels are activated. However, the gating mechanism that allows Ca<sup>2+</sup> permeation through Orai channels is less well explained. Here, we reviewed and summarized the existing structural studies of Orai channels. We detailed the structural features of Orai channels, described structural comparisons of their closed and open states, and finally proposed a “push–pull” model of Ca<sup>2+</sup> permeation.Yang LiXue YangYuequan ShenMDPI AGarticleOraiCa<sup>2+</sup> channelSTIMSOCECRAC channelCa<sup>2+</sup> permeationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3062, p 3062 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Orai Ca<sup>2+</sup> channel STIM SOCE CRAC channel Ca<sup>2+</sup> permeation Biology (General) QH301-705.5 |
| spellingShingle |
Orai Ca<sup>2+</sup> channel STIM SOCE CRAC channel Ca<sup>2+</sup> permeation Biology (General) QH301-705.5 Yang Li Xue Yang Yuequan Shen Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| description |
Orai channels belong to the calcium release-activated calcium (CRAC) channel family. Orai channels are responsible for the influx of extracellular Ca<sup>2+</sup> that is triggered by Ca<sup>2+</sup> depletion from the endoplasmic reticulum (ER); this function is essential for many types of non-excitable cells. Extensive structural and functional studies have advanced the knowledge of the molecular mechanism by which Orai channels are activated. However, the gating mechanism that allows Ca<sup>2+</sup> permeation through Orai channels is less well explained. Here, we reviewed and summarized the existing structural studies of Orai channels. We detailed the structural features of Orai channels, described structural comparisons of their closed and open states, and finally proposed a “push–pull” model of Ca<sup>2+</sup> permeation. |
| format |
article |
| author |
Yang Li Xue Yang Yuequan Shen |
| author_facet |
Yang Li Xue Yang Yuequan Shen |
| author_sort |
Yang Li |
| title |
Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| title_short |
Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| title_full |
Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| title_fullStr |
Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| title_full_unstemmed |
Structural Insights into Ca<sup>2+</sup> Permeation through Orai Channels |
| title_sort |
structural insights into ca<sup>2+</sup> permeation through orai channels |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/5271a58d50704360b9a22cad80179e2b |
| work_keys_str_mv |
AT yangli structuralinsightsintocasup2suppermeationthroughoraichannels AT xueyang structuralinsightsintocasup2suppermeationthroughoraichannels AT yuequanshen structuralinsightsintocasup2suppermeationthroughoraichannels |
| _version_ |
1718412648702279680 |