Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine

Metronidazole is a highly effective active antibacterial against trichomoniasis and protozoan infections. A ZnO nanoparticle-modified graphite carbon paste electrode was constructed as an electrochemical sensor for the electroanalysis of metronidazole. The electro-catalytic properties of the ZnO@CPE...

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Autores principales:	Jallal. Zoubir, C. Radaa, N. Bougdour, A. Idlahcen, I. Bakas, A. Assabbane
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Metronidazole Antibacterial Carbon graphite ZnO@CPE Electro catalytic Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
Acceso en línea:	https://doaj.org/article/5277470c8c0f4d6ea849822e8d6c40a2
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spelling	oai:doaj.org-article:5277470c8c0f4d6ea849822e8d6c40a22021-11-30T04:16:58ZElectro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine2589-299110.1016/j.mset.2021.06.001https://doaj.org/article/5277470c8c0f4d6ea849822e8d6c40a22021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589299121000161https://doaj.org/toc/2589-2991Metronidazole is a highly effective active antibacterial against trichomoniasis and protozoan infections. A ZnO nanoparticle-modified graphite carbon paste electrode was constructed as an electrochemical sensor for the electroanalysis of metronidazole. The electro-catalytic properties of the ZnO@CPE electrode were examined by cyclic voltammetry and EIS. Zinc oxide nanoparticles synthesized on graphite carbon nanosheets by thermal route under studied and optimized experimental conditions were found to have excellent electro-catalytic performance for the reduction of metronidazole traces. The relationship between pH and Epc gave a slope of −59 mV/ZnO@CPE in the pH range of 4.5 to 9.5. Reflecting that the number of electrons and protons participating in the reaction convert the ϕ-NO2 attractor groups of Metronidazole molecules on the electro-catalytic surface of the fabricated electrode are equal. The morphology analysis of the fabricated electrode surface indicates the formation of zinc oxide crystals, the XRD study confirms the crystal structure of the hexagonal phase of ZnO. The calibration curve was constructed by the differential pulse voltameter method in the concentration range of 0.8–100 µmol L−1, with a limit of detection and limit of quantification of metronidazole equal to 1.018 10−7 M and 3.395 10−7 M respectively. The proposed method has been successfully tested for the detection of trace amounts of metronidazole in real samples such as urine and serum. The proposed method is also simple, fast and inexpensive. It has a good recovery rate, good selectivity and high sensitivity.Jallal. ZoubirC. RadaaN. BougdourA. IdlahcenI. BakasA. AssabbaneKeAi Communications Co., Ltd.articleMetronidazoleAntibacterialCarbon graphiteZnO@CPEElectro catalyticMaterials of engineering and construction. Mechanics of materialsTA401-492Energy conservationTJ163.26-163.5ENMaterials Science for Energy Technologies, Vol 4, Iss , Pp 177-188 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Metronidazole Antibacterial Carbon graphite ZnO@CPE Electro catalytic Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5
spellingShingle	Metronidazole Antibacterial Carbon graphite ZnO@CPE Electro catalytic Materials of engineering and construction. Mechanics of materials TA401-492 Energy conservation TJ163.26-163.5 Jallal. Zoubir C. Radaa N. Bougdour A. Idlahcen I. Bakas A. Assabbane Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
description	Metronidazole is a highly effective active antibacterial against trichomoniasis and protozoan infections. A ZnO nanoparticle-modified graphite carbon paste electrode was constructed as an electrochemical sensor for the electroanalysis of metronidazole. The electro-catalytic properties of the ZnO@CPE electrode were examined by cyclic voltammetry and EIS. Zinc oxide nanoparticles synthesized on graphite carbon nanosheets by thermal route under studied and optimized experimental conditions were found to have excellent electro-catalytic performance for the reduction of metronidazole traces. The relationship between pH and Epc gave a slope of −59 mV/ZnO@CPE in the pH range of 4.5 to 9.5. Reflecting that the number of electrons and protons participating in the reaction convert the ϕ-NO2 attractor groups of Metronidazole molecules on the electro-catalytic surface of the fabricated electrode are equal. The morphology analysis of the fabricated electrode surface indicates the formation of zinc oxide crystals, the XRD study confirms the crystal structure of the hexagonal phase of ZnO. The calibration curve was constructed by the differential pulse voltameter method in the concentration range of 0.8–100 µmol L−1, with a limit of detection and limit of quantification of metronidazole equal to 1.018 10−7 M and 3.395 10−7 M respectively. The proposed method has been successfully tested for the detection of trace amounts of metronidazole in real samples such as urine and serum. The proposed method is also simple, fast and inexpensive. It has a good recovery rate, good selectivity and high sensitivity.
format	article
author	Jallal. Zoubir C. Radaa N. Bougdour A. Idlahcen I. Bakas A. Assabbane
author_facet	Jallal. Zoubir C. Radaa N. Bougdour A. Idlahcen I. Bakas A. Assabbane
author_sort	Jallal. Zoubir
title	Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
title_short	Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
title_full	Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
title_fullStr	Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
title_full_unstemmed	Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine
title_sort	electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. analytical application: human serum and urine
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/5277470c8c0f4d6ea849822e8d6c40a2
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Electro-detection of the antibacterial metronidazole using zinc oxide nanoparticles formed on graphitic carbon sheets. Analytical application: Human serum and urine

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