The beta secretase BACE1 regulates the expression of insulin receptor in the liver

A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent manner, both in physiological and diabetic conditio...

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Autores principales:	Paul J. Meakin, Anna Mezzapesa, Eva Benabou, Mary E. Haas, Bernadette Bonardo, Michel Grino, Jean-Michel Brunel, Christèle Desbois-Mouthon, Sudha B. Biddinger, Roland Govers, Michael L. J. Ashford, Franck Peiretti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc213
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spelling	oai:doaj.org-article:527a3cb8a7ee44ba84d8fe3536cdc2132021-12-02T17:31:13ZThe beta secretase BACE1 regulates the expression of insulin receptor in the liver10.1038/s41467-018-03755-22041-1723https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc2132018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03755-2https://doaj.org/toc/2041-1723A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent manner, both in physiological and diabetic conditions.Paul J. MeakinAnna MezzapesaEva BenabouMary E. HaasBernadette BonardoMichel GrinoJean-Michel BrunelChristèle Desbois-MouthonSudha B. BiddingerRoland GoversMichael L. J. AshfordFranck PeirettiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul J. Meakin Anna Mezzapesa Eva Benabou Mary E. Haas Bernadette Bonardo Michel Grino Jean-Michel Brunel Christèle Desbois-Mouthon Sudha B. Biddinger Roland Govers Michael L. J. Ashford Franck Peiretti The beta secretase BACE1 regulates the expression of insulin receptor in the liver
description	A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent manner, both in physiological and diabetic conditions.
format	article
author	Paul J. Meakin Anna Mezzapesa Eva Benabou Mary E. Haas Bernadette Bonardo Michel Grino Jean-Michel Brunel Christèle Desbois-Mouthon Sudha B. Biddinger Roland Govers Michael L. J. Ashford Franck Peiretti
author_facet	Paul J. Meakin Anna Mezzapesa Eva Benabou Mary E. Haas Bernadette Bonardo Michel Grino Jean-Michel Brunel Christèle Desbois-Mouthon Sudha B. Biddinger Roland Govers Michael L. J. Ashford Franck Peiretti
author_sort	Paul J. Meakin
title	The beta secretase BACE1 regulates the expression of insulin receptor in the liver
title_short	The beta secretase BACE1 regulates the expression of insulin receptor in the liver
title_full	The beta secretase BACE1 regulates the expression of insulin receptor in the liver
title_fullStr	The beta secretase BACE1 regulates the expression of insulin receptor in the liver
title_full_unstemmed	The beta secretase BACE1 regulates the expression of insulin receptor in the liver
title_sort	beta secretase bace1 regulates the expression of insulin receptor in the liver
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/527a3cb8a7ee44ba84d8fe3536cdc213
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver

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