An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide variety of cationic cargo in numerous cell types.

Guardado en:

Detalles Bibliográficos
Autores principales:	Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:527a6ef95d124979b5fd95a610cb9fb1
record_format	dspace
spelling	oai:doaj.org-article:527a6ef95d124979b5fd95a610cb9fb12021-12-02T15:35:07ZAn anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles10.1038/s41467-019-12906-y2041-1723https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb12019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12906-yhttps://doaj.org/toc/2041-1723Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide variety of cationic cargo in numerous cell types.Brian C. EvansR. Brock FletcherKameron V. KilchristEric A. DailingAlvin J. MukalelJuan M. ColazoMatthew OliverJoyce Cheung-FlynnColleen M. BrophyJohn W. TierneyJeffrey S. IsenbergKurt D. HankensonKedar GhimireCynthia LanderCharles A. GersbachCraig L. DuvallNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brian C. Evans R. Brock Fletcher Kameron V. Kilchrist Eric A. Dailing Alvin J. Mukalel Juan M. Colazo Matthew Oliver Joyce Cheung-Flynn Colleen M. Brophy John W. Tierney Jeffrey S. Isenberg Kurt D. Hankenson Kedar Ghimire Cynthia Lander Charles A. Gersbach Craig L. Duvall An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
description	Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide variety of cationic cargo in numerous cell types.
format	article
author	Brian C. Evans R. Brock Fletcher Kameron V. Kilchrist Eric A. Dailing Alvin J. Mukalel Juan M. Colazo Matthew Oliver Joyce Cheung-Flynn Colleen M. Brophy John W. Tierney Jeffrey S. Isenberg Kurt D. Hankenson Kedar Ghimire Cynthia Lander Charles A. Gersbach Craig L. Duvall
author_facet	Brian C. Evans R. Brock Fletcher Kameron V. Kilchrist Eric A. Dailing Alvin J. Mukalel Juan M. Colazo Matthew Oliver Joyce Cheung-Flynn Colleen M. Brophy John W. Tierney Jeffrey S. Isenberg Kurt D. Hankenson Kedar Ghimire Cynthia Lander Charles A. Gersbach Craig L. Duvall
author_sort	Brian C. Evans
title	An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
title_short	An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
title_full	An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
title_fullStr	An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
title_full_unstemmed	An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
title_sort	anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
work_keys_str_mv	AT briancevans ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT rbrockfletcher ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kameronvkilchrist ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT ericadailing ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT alvinjmukalel ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT juanmcolazo ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT matthewoliver ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT joycecheungflynn ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT colleenmbrophy ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT johnwtierney ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT jeffreysisenberg ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kurtdhankenson ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kedarghimire ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT cynthialander ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT charlesagersbach ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT craiglduvall ananionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT briancevans anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT rbrockfletcher anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kameronvkilchrist anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT ericadailing anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT alvinjmukalel anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT juanmcolazo anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT matthewoliver anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT joycecheungflynn anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT colleenmbrophy anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT johnwtierney anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT jeffreysisenberg anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kurtdhankenson anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT kedarghimire anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT cynthialander anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT charlesagersbach anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles AT craiglduvall anionicendosomeescapingpolymertopotentiateintracellulardeliveryofcationicpeptidesbiomacromoleculesandnanoparticles
_version_	1718386654527356928

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Ejemplares similares