An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide variety of cationic cargo in numerous cell types.

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Bibliographic Details
Main Authors: Brian C. Evans, R. Brock Fletcher, Kameron V. Kilchrist, Eric A. Dailing, Alvin J. Mukalel, Juan M. Colazo, Matthew Oliver, Joyce Cheung-Flynn, Colleen M. Brophy, John W. Tierney, Jeffrey S. Isenberg, Kurt D. Hankenson, Kedar Ghimire, Cynthia Lander, Charles A. Gersbach, Craig L. Duvall
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Science
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Online Access:https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1
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Internet

https://doaj.org/article/527a6ef95d124979b5fd95a610cb9fb1

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