Differential effects of body mass index on domain-specific cognitive outcomes after stroke

Abstract Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outco...

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Autores principales:	Minwoo Lee, Mi Sun Oh, San Jung, Ju-Hun Lee, Chul-Ho Kim, Min Uk Jang, Young Eun Kim, Hee-Joon Bae, Jaeseol Park, Yeonwook Kang, Byung-Chul Lee, Jae-Sung Lim, Kyung-Ho Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/527b80f2daf349498d298cde372caf3e
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spelling	oai:doaj.org-article:527b80f2daf349498d298cde372caf3e2021-12-02T15:23:17ZDifferential effects of body mass index on domain-specific cognitive outcomes after stroke10.1038/s41598-021-93714-72045-2322https://doaj.org/article/527b80f2daf349498d298cde372caf3e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93714-7https://doaj.org/toc/2045-2322Abstract Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focusing on the subdivision of each frontal domain function in post-ischemic stroke survivors. A total of 335 ischemic stroke patients were included in the study after completion of the Korean-Mini Mental Status Examination (K-MMSE) and the vascular cognitive impairment harmonization standards neuropsychological protocol at 3 months after stroke. Frontal lobe functions were analyzed using semantic/phonemic fluency, processing speed, and mental set shifting. Our study participants were categorized into four groups according to BMI quartiles. The z-scores of K-MMSE at 3 months differed significantly between the groups after adjustment for initial stroke severity (p = 0.014). Global cognitive function in stroke survivors in the Q1 (the lowest quartile) BMI group was significantly lower than those in Q2 and Q4 (the highest quartile) BMI groups (K-MMSE z-scores, Q1: − 2.10 ± 3.40 vs. Q2: 0.71 ± 1.95 and Q4: − 1.21 ± 1.65). Controlled oral word association test findings indicated that phonemic and semantic word fluency was lower in Q4 BMI group participants than in Q2 BMI group participants (p = 0.016 and p = 0.023 respectively). BMI might differentially affect cognitive domains after ischemic stroke. Although being underweight may negatively affect global cognition post-stroke, obesity could induce frontal lobe dysfunctions, specifically phonemic and semantic word fluency.Minwoo LeeMi Sun OhSan JungJu-Hun LeeChul-Ho KimMin Uk JangYoung Eun KimHee-Joon BaeJaeseol ParkYeonwook KangByung-Chul LeeJae-Sung LimKyung-Ho YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Minwoo Lee Mi Sun Oh San Jung Ju-Hun Lee Chul-Ho Kim Min Uk Jang Young Eun Kim Hee-Joon Bae Jaeseol Park Yeonwook Kang Byung-Chul Lee Jae-Sung Lim Kyung-Ho Yu Differential effects of body mass index on domain-specific cognitive outcomes after stroke
description	Abstract Although the obesity paradox is an important modifiable factor in cardiovascular diseases, little research has been conducted to determine how it affects post-stroke cognitive function. We aimed to investigate the association between body mass index (BMI) and domain-specific cognitive outcomes, focusing on the subdivision of each frontal domain function in post-ischemic stroke survivors. A total of 335 ischemic stroke patients were included in the study after completion of the Korean-Mini Mental Status Examination (K-MMSE) and the vascular cognitive impairment harmonization standards neuropsychological protocol at 3 months after stroke. Frontal lobe functions were analyzed using semantic/phonemic fluency, processing speed, and mental set shifting. Our study participants were categorized into four groups according to BMI quartiles. The z-scores of K-MMSE at 3 months differed significantly between the groups after adjustment for initial stroke severity (p = 0.014). Global cognitive function in stroke survivors in the Q1 (the lowest quartile) BMI group was significantly lower than those in Q2 and Q4 (the highest quartile) BMI groups (K-MMSE z-scores, Q1: − 2.10 ± 3.40 vs. Q2: 0.71 ± 1.95 and Q4: − 1.21 ± 1.65). Controlled oral word association test findings indicated that phonemic and semantic word fluency was lower in Q4 BMI group participants than in Q2 BMI group participants (p = 0.016 and p = 0.023 respectively). BMI might differentially affect cognitive domains after ischemic stroke. Although being underweight may negatively affect global cognition post-stroke, obesity could induce frontal lobe dysfunctions, specifically phonemic and semantic word fluency.
format	article
author	Minwoo Lee Mi Sun Oh San Jung Ju-Hun Lee Chul-Ho Kim Min Uk Jang Young Eun Kim Hee-Joon Bae Jaeseol Park Yeonwook Kang Byung-Chul Lee Jae-Sung Lim Kyung-Ho Yu
author_facet	Minwoo Lee Mi Sun Oh San Jung Ju-Hun Lee Chul-Ho Kim Min Uk Jang Young Eun Kim Hee-Joon Bae Jaeseol Park Yeonwook Kang Byung-Chul Lee Jae-Sung Lim Kyung-Ho Yu
author_sort	Minwoo Lee
title	Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_short	Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_full	Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_fullStr	Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_full_unstemmed	Differential effects of body mass index on domain-specific cognitive outcomes after stroke
title_sort	differential effects of body mass index on domain-specific cognitive outcomes after stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/527b80f2daf349498d298cde372caf3e
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Differential effects of body mass index on domain-specific cognitive outcomes after stroke

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