Temperature- and pH-sensitive wearable materials for monitoring foot ulcers

Pietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council o...

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Autores principales:	Salvo P, Calisi N, Melai B, Dini V, Paoletti C, Lomonaco T, Pucci A, Di Francesco F, Piaggesi A, Romanelli M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	diabetic foot ulcer wearable sensors wound temperature wound pH. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/527c05244d924182a9813718d9b74e64
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spelling	oai:doaj.org-article:527c05244d924182a9813718d9b74e642021-12-02T02:41:38ZTemperature- and pH-sensitive wearable materials for monitoring foot ulcers1178-2013https://doaj.org/article/527c05244d924182a9813718d9b74e642017-01-01T00:00:00Zhttps://www.dovepress.com/temperature-and-ph-sensitive-wearable-materials-for-monitoring-foot-ul-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Pietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council of Research, 3Wound Healing Research Unit, Department of Dermatology, University of Pisa, 4Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, Italy Abstract: Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Temperature is measured by exploiting the variations in the electrical resistance of a nanocomposite consisting of multiwalled carbon nanotubes and poly(styrene-b-(ethylene-co-butylene)-b-styrene). The pH sensor used a graphene oxide (GO) layer that changes its electrical potential when pH changes. The temperature sensor has a sensitivity of ~85 Ω/°C in the range 25°C–50°C and a high repeatability (maximum standard deviation of 0.1% over seven repeated measurements). For a GO concentration of 4 mg/mL, the pH sensor has a sensitivity of ~42 mV/pH and high linearity (R2=0.99). Keywords: diabetic foot ulcer, wearable sensors, wound temperature, wound pHSalvo PCalisi NMelai BDini VPaoletti CLomonaco TPucci ADi Francesco FPiaggesi ARomanelli MDove Medical Pressarticlediabetic foot ulcerwearable sensorswound temperaturewound pH.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 949-954 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic foot ulcer wearable sensors wound temperature wound pH. Medicine (General) R5-920
spellingShingle	diabetic foot ulcer wearable sensors wound temperature wound pH. Medicine (General) R5-920 Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
description	Pietro Salvo,1,2 Nicola Calisi,1 Bernardo Melai,1 Valentina Dini,3 Clara Paoletti,1 Tommaso Lomonaco,1 Andrea Pucci,1 Fabio Di Francesco,1 Alberto Piaggesi,4 Marco Romanelli3 1Department of Chemistry and Industrial Chemistry, University of Pisa, 2Institute of Clinical Physiology, National Council of Research, 3Wound Healing Research Unit, Department of Dermatology, University of Pisa, 4Diabetic Foot Section, Department of Medicine, University of Pisa, Pisa, Italy Abstract: Foot ulcers account for 15% of comorbidities associated with diabetes. Presently, no device allows the status of foot ulcers to be continuously monitored when patients are not hospitalized. In this study, we describe a temperature and a pH sensor capable of monitoring diabetic foot and venous leg ulcers developed in the frame of the seventh framework program European Union project SWAN-iCare (smart wearable and autonomous negative pressure device for wound monitoring and therapy). Temperature is measured by exploiting the variations in the electrical resistance of a nanocomposite consisting of multiwalled carbon nanotubes and poly(styrene-b-(ethylene-co-butylene)-b-styrene). The pH sensor used a graphene oxide (GO) layer that changes its electrical potential when pH changes. The temperature sensor has a sensitivity of ~85 Ω/°C in the range 25°C–50°C and a high repeatability (maximum standard deviation of 0.1% over seven repeated measurements). For a GO concentration of 4 mg/mL, the pH sensor has a sensitivity of ~42 mV/pH and high linearity (R2=0.99). Keywords: diabetic foot ulcer, wearable sensors, wound temperature, wound pH
format	article
author	Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M
author_facet	Salvo P Calisi N Melai B Dini V Paoletti C Lomonaco T Pucci A Di Francesco F Piaggesi A Romanelli M
author_sort	Salvo P
title	Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
title_short	Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
title_full	Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
title_fullStr	Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
title_full_unstemmed	Temperature- and pH-sensitive wearable materials for monitoring foot ulcers
title_sort	temperature- and ph-sensitive wearable materials for monitoring foot ulcers
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/527c05244d924182a9813718d9b74e64
work_keys_str_mv	AT salvop temperatureandphsensitivewearablematerialsformonitoringfootulcers AT calisin temperatureandphsensitivewearablematerialsformonitoringfootulcers AT melaib temperatureandphsensitivewearablematerialsformonitoringfootulcers AT diniv temperatureandphsensitivewearablematerialsformonitoringfootulcers AT paolettic temperatureandphsensitivewearablematerialsformonitoringfootulcers AT lomonacot temperatureandphsensitivewearablematerialsformonitoringfootulcers AT puccia temperatureandphsensitivewearablematerialsformonitoringfootulcers AT difrancescof temperatureandphsensitivewearablematerialsformonitoringfootulcers AT piaggesia temperatureandphsensitivewearablematerialsformonitoringfootulcers AT romanellim temperatureandphsensitivewearablematerialsformonitoringfootulcers
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Temperature- and pH-sensitive wearable materials for monitoring foot ulcers

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