Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice

Abstract Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organs. Recent studies suggest relevance between cysteine protease cathepsin S (CTSS) expression and SLE. To investigate the mechanism of CTSS in SLE, CTSS-overexpressing transgenic (TG) mice were gener...

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Autores principales: Jinhee Lee, Soyoung Jang, Minjee Choi, Mincheol Kang, Su-Geun Lim, SI-Yong Kim, Soyeon Jang, Jiwon Ko, Eungyung Kim, Junkoo Yi, Yeonsik Choo, Myoung Ok Kim, Zae Young Ryoo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/527c6365fe894cf79ff097e3b7400ebd
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