Suppression of plant resistance gene-based immunity by a fungal effector.

The innate immune system of plants consists of two layers. The first layer, called basal resistance, governs recognition of conserved microbial molecules and fends off most attempted invasions. The second layer is based on Resistance (R) genes that mediate recognition of effectors, proteins secreted...

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Autores principales:	Petra M Houterman, Ben J C Cornelissen, Martijn Rep
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/527d36e30a86453990e554a29cca4d1d
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spelling	oai:doaj.org-article:527d36e30a86453990e554a29cca4d1d2021-11-25T05:46:35ZSuppression of plant resistance gene-based immunity by a fungal effector.1553-73661553-737410.1371/journal.ppat.1000061https://doaj.org/article/527d36e30a86453990e554a29cca4d1d2008-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18464895/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The innate immune system of plants consists of two layers. The first layer, called basal resistance, governs recognition of conserved microbial molecules and fends off most attempted invasions. The second layer is based on Resistance (R) genes that mediate recognition of effectors, proteins secreted by pathogens to suppress or evade basal resistance. Here, we show that a plant-pathogenic fungus secretes an effector that can both trigger and suppress R gene-based immunity. This effector, Avr1, is secreted by the xylem-invading fungus Fusarium oxysporum f.sp. lycopersici (Fol) and triggers disease resistance when the host plant, tomato, carries a matching R gene (I or I-1). At the same time, Avr1 suppresses the protective effect of two other R genes, I-2 and I-3. Based on these observations, we tentatively reconstruct the evolutionary arms race that has taken place between tomato R genes and effectors of Fol. This molecular analysis has revealed a hitherto unpredicted strategy for durable disease control based on resistance gene combinations.Petra M HoutermanBen J C CornelissenMartijn RepPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 5, p e1000061 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Petra M Houterman Ben J C Cornelissen Martijn Rep Suppression of plant resistance gene-based immunity by a fungal effector.
description	The innate immune system of plants consists of two layers. The first layer, called basal resistance, governs recognition of conserved microbial molecules and fends off most attempted invasions. The second layer is based on Resistance (R) genes that mediate recognition of effectors, proteins secreted by pathogens to suppress or evade basal resistance. Here, we show that a plant-pathogenic fungus secretes an effector that can both trigger and suppress R gene-based immunity. This effector, Avr1, is secreted by the xylem-invading fungus Fusarium oxysporum f.sp. lycopersici (Fol) and triggers disease resistance when the host plant, tomato, carries a matching R gene (I or I-1). At the same time, Avr1 suppresses the protective effect of two other R genes, I-2 and I-3. Based on these observations, we tentatively reconstruct the evolutionary arms race that has taken place between tomato R genes and effectors of Fol. This molecular analysis has revealed a hitherto unpredicted strategy for durable disease control based on resistance gene combinations.
format	article
author	Petra M Houterman Ben J C Cornelissen Martijn Rep
author_facet	Petra M Houterman Ben J C Cornelissen Martijn Rep
author_sort	Petra M Houterman
title	Suppression of plant resistance gene-based immunity by a fungal effector.
title_short	Suppression of plant resistance gene-based immunity by a fungal effector.
title_full	Suppression of plant resistance gene-based immunity by a fungal effector.
title_fullStr	Suppression of plant resistance gene-based immunity by a fungal effector.
title_full_unstemmed	Suppression of plant resistance gene-based immunity by a fungal effector.
title_sort	suppression of plant resistance gene-based immunity by a fungal effector.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/527d36e30a86453990e554a29cca4d1d
work_keys_str_mv	AT petramhouterman suppressionofplantresistancegenebasedimmunitybyafungaleffector AT benjccornelissen suppressionofplantresistancegenebasedimmunitybyafungaleffector AT martijnrep suppressionofplantresistancegenebasedimmunitybyafungaleffector
_version_	1718414457465470976

Suppression of plant resistance gene-based immunity by a fungal effector.

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