Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel

Abstract Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible,...

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Autores principales:	Massimiliano Papi, Valentina Palmieri, Francesca Bugli, Marco De Spirito, Maurizio Sanguinetti, Carlotta Ciancico, Maria Chiara Braidotti, Silvia Gentilini, Luca Angelani, Claudio Conti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5282c08d36534bcb8abb7338571346be
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spelling	oai:doaj.org-article:5282c08d36534bcb8abb7338571346be2021-12-02T15:06:06ZBiomimetic antimicrobial cloak by graphene-oxide agar hydrogel10.1038/s41598-016-0010-72045-2322https://doaj.org/article/5282c08d36534bcb8abb7338571346be2016-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-016-0010-7https://doaj.org/toc/2045-2322Abstract Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces. Here we demonstrate an antibacterial cloak by laser printing of graphene oxide hydrogels mimicking the Cancer Pagurus carapace. We observe up to 90% reduction of bacteria cells. This cloak exploits natural surface patterns evolved to resist to microorganisms infection, and the antimicrobial efficacy of graphene oxide. Cell integrity analysis by scanning electron microscopy and nucleic acids release show bacteriostatic and bactericidal effect. Nucleic acids release demonstrates microorganism cutting, and microscopy reveals cells wrapped by the laser treated gel. A theoretical active matter model confirms our findings. The employment of biomimetic graphene oxide gels opens unique possibilities to decrease infections in biomedical applications and chirurgical equipment; our antibiotic-free approach, based on the geometric reduction of microbial adhesion and the mechanical action of Graphene Oxide sheets, is potentially not affected by bacterial resistance.Massimiliano PapiValentina PalmieriFrancesca BugliMarco De SpiritoMaurizio SanguinettiCarlotta CiancicoMaria Chiara BraidottiSilvia GentiliniLuca AngelaniClaudio ContiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 6, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Massimiliano Papi Valentina Palmieri Francesca Bugli Marco De Spirito Maurizio Sanguinetti Carlotta Ciancico Maria Chiara Braidotti Silvia Gentilini Luca Angelani Claudio Conti Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
description	Abstract Antibacterial surfaces have an enormous economic and social impact on the worldwide technological fight against diseases. However, bacteria develop resistance and coatings are often not uniform and not stable in time. The challenge is finding an antibacterial coating that is biocompatible, cost-effective, not toxic, and spreadable over large and irregular surfaces. Here we demonstrate an antibacterial cloak by laser printing of graphene oxide hydrogels mimicking the Cancer Pagurus carapace. We observe up to 90% reduction of bacteria cells. This cloak exploits natural surface patterns evolved to resist to microorganisms infection, and the antimicrobial efficacy of graphene oxide. Cell integrity analysis by scanning electron microscopy and nucleic acids release show bacteriostatic and bactericidal effect. Nucleic acids release demonstrates microorganism cutting, and microscopy reveals cells wrapped by the laser treated gel. A theoretical active matter model confirms our findings. The employment of biomimetic graphene oxide gels opens unique possibilities to decrease infections in biomedical applications and chirurgical equipment; our antibiotic-free approach, based on the geometric reduction of microbial adhesion and the mechanical action of Graphene Oxide sheets, is potentially not affected by bacterial resistance.
format	article
author	Massimiliano Papi Valentina Palmieri Francesca Bugli Marco De Spirito Maurizio Sanguinetti Carlotta Ciancico Maria Chiara Braidotti Silvia Gentilini Luca Angelani Claudio Conti
author_facet	Massimiliano Papi Valentina Palmieri Francesca Bugli Marco De Spirito Maurizio Sanguinetti Carlotta Ciancico Maria Chiara Braidotti Silvia Gentilini Luca Angelani Claudio Conti
author_sort	Massimiliano Papi
title	Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
title_short	Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
title_full	Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
title_fullStr	Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
title_full_unstemmed	Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
title_sort	biomimetic antimicrobial cloak by graphene-oxide agar hydrogel
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5282c08d36534bcb8abb7338571346be
work_keys_str_mv	AT massimilianopapi biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT valentinapalmieri biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT francescabugli biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT marcodespirito biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT mauriziosanguinetti biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT carlottaciancico biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT mariachiarabraidotti biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT silviagentilini biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT lucaangelani biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel AT claudioconti biomimeticantimicrobialcloakbygrapheneoxideagarhydrogel
_version_	1718388582582845440

Biomimetic antimicrobial cloak by graphene-oxide agar hydrogel

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