ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS

Psoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthr...

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Autores principales:	M. V. Smolnikova, S. V. Smirnova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	genes polymorphism psoriatic arthritis interleukin Science Q
Acceso en línea:	https://doaj.org/article/5284335d8ff14a11a7c25d173f21b4a3
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spelling	oai:doaj.org-article:5284335d8ff14a11a7c25d173f21b4a32021-11-23T06:14:19ZASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS2541-94202587-9596https://doaj.org/article/5284335d8ff14a11a7c25d173f21b4a32012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/915https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Psoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthritis development is proposed with essential role of genes coding for cytokines, the main mediators of immune response. A study of the prevalence of polymorphisms of the genes of anti-inflammatory cytokines IL4 (C-590T) and IL10 (C-597A) in patients with psoriasis, psoriatic arthritis and healthy donors was carried out. The prevalence of the polymorphisms in the European population of Krasnoyarsk was obtained. An association of the C-590T polymorphic marker of the promoter region of the IL4 gene with psoriatic arthritis was established. The obtained results suggest that the C-590 allele is a contributing factor to heavier course of psoriasis and the development of bone system pathology.M. V. SmolnikovaS. V. SmirnovaScientific Сentre for Family Health and Human Reproduction Problemsarticlegenes polymorphismpsoriatic arthritisinterleukinScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 190-193 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	genes polymorphism psoriatic arthritis interleukin Science Q
spellingShingle	genes polymorphism psoriatic arthritis interleukin Science Q M. V. Smolnikova S. V. Smirnova ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
description	Psoriatic arthritis is a chronic progressive disease of joints developing along with psoriasis. Likewise arthritis and psoriasis alone, it represents the systemic multifactorial disease of unknown etiology; therefore prevention of the disease is inefficient. Genetic predisposition to psoriatic arthritis development is proposed with essential role of genes coding for cytokines, the main mediators of immune response. A study of the prevalence of polymorphisms of the genes of anti-inflammatory cytokines IL4 (C-590T) and IL10 (C-597A) in patients with psoriasis, psoriatic arthritis and healthy donors was carried out. The prevalence of the polymorphisms in the European population of Krasnoyarsk was obtained. An association of the C-590T polymorphic marker of the promoter region of the IL4 gene with psoriatic arthritis was established. The obtained results suggest that the C-590 allele is a contributing factor to heavier course of psoriasis and the development of bone system pathology.
format	article
author	M. V. Smolnikova S. V. Smirnova
author_facet	M. V. Smolnikova S. V. Smirnova
author_sort	M. V. Smolnikova
title	ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
title_short	ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
title_full	ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
title_fullStr	ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
title_full_unstemmed	ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS
title_sort	association between polymorphic markers of the il4 (с-590т) and il10 (с-597а) genes and psoriatic arthritis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/5284335d8ff14a11a7c25d173f21b4a3
work_keys_str_mv	AT mvsmolnikova associationbetweenpolymorphicmarkersoftheil4s590tandil10s597agenesandpsoriaticarthritis AT svsmirnova associationbetweenpolymorphicmarkersoftheil4s590tandil10s597agenesandpsoriaticarthritis
_version_	1718417317211144192

ASSOCIATION BETWEEN POLYMORPHIC MARKERS OF THE IL4 (с-590Т) AND IL10 (с-597А) GENES AND PSORIATIC ARTHRITIS

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