Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes

Diseases can be associated with various mutations of the same gene, but the molecular consequences of specific mutations remain incompletely understood. Here, the authors present an integrated proteomic workflow to determine the molecular response of cells to different cancer-associated mutations of...

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Autores principales:	Martin Mehnert, Rodolfo Ciuffa, Fabian Frommelt, Federico Uliana, Audrey van Drogen, Kilian Ruminski, Matthias Gstaiger, Ruedi Aebersold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5284796b9f7e4306aca01803fd9b2199
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spelling	oai:doaj.org-article:5284796b9f7e4306aca01803fd9b21992021-12-02T18:31:30ZMulti-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes10.1038/s41467-020-17387-y2041-1723https://doaj.org/article/5284796b9f7e4306aca01803fd9b21992020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17387-yhttps://doaj.org/toc/2041-1723Diseases can be associated with various mutations of the same gene, but the molecular consequences of specific mutations remain incompletely understood. Here, the authors present an integrated proteomic workflow to determine the molecular response of cells to different cancer-associated mutations of the kinase Dyrk2.Martin MehnertRodolfo CiuffaFabian FrommeltFederico UlianaAudrey van DrogenKilian RuminskiMatthias GstaigerRuedi AebersoldNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Mehnert Rodolfo Ciuffa Fabian Frommelt Federico Uliana Audrey van Drogen Kilian Ruminski Matthias Gstaiger Ruedi Aebersold Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
description	Diseases can be associated with various mutations of the same gene, but the molecular consequences of specific mutations remain incompletely understood. Here, the authors present an integrated proteomic workflow to determine the molecular response of cells to different cancer-associated mutations of the kinase Dyrk2.
format	article
author	Martin Mehnert Rodolfo Ciuffa Fabian Frommelt Federico Uliana Audrey van Drogen Kilian Ruminski Matthias Gstaiger Ruedi Aebersold
author_facet	Martin Mehnert Rodolfo Ciuffa Fabian Frommelt Federico Uliana Audrey van Drogen Kilian Ruminski Matthias Gstaiger Ruedi Aebersold
author_sort	Martin Mehnert
title	Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
title_short	Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
title_full	Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
title_fullStr	Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
title_full_unstemmed	Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
title_sort	multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5284796b9f7e4306aca01803fd9b2199
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Multi-layered proteomic analyses decode compositional and functional effects of cancer mutations on kinase complexes

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