Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer

Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists...

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Autores principales:	Morvarid Siri, Seyed Vahid Hosseini, Sanaz Dastghaib, Pooneh Mokarram
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2020
Materias:	endoplasmic reticulum stress cancer upr wnt Medicine R
Acceso en línea:	https://doaj.org/article/528b21c058b244bf89ed4213525b77ec
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spelling	oai:doaj.org-article:528b21c058b244bf89ed4213525b77ec2021-11-14T08:12:06ZCrosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer2783-243010.30476/acrr.2020.46538https://doaj.org/article/528b21c058b244bf89ed4213525b77ec2020-03-01T00:00:00Zhttps://colorectalresearch.sums.ac.ir/article_46538_1e80213e37224b3916d6264810d9b07f.pdfhttps://doaj.org/toc/2783-2430Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.Morvarid SiriSeyed Vahid HosseiniSanaz DastghaibPooneh MokarramShiraz University of Medical Sciencesarticleendoplasmic reticulumstresscanceruprwntMedicineRENIranian Journal of Colorectal Research, Vol 8, Iss 1, Pp 9-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	endoplasmic reticulum stress cancer upr wnt Medicine R
spellingShingle	endoplasmic reticulum stress cancer upr wnt Medicine R Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
description	Abstract: 1. Context Endoplasmic reticulum stress (ER stess) is associated with endoplasmic reticulum perturbation homeostasis. Prolonged ER stress conditions may induce cell death. Unfolded protein response (UPR) attempts to restore normal cell conditions. 2. Evidence Acquisition There now exists an emergent body of evidence identifying the WNT signaling network as a regulator of cancer cell metabolism. Given that existing findings show that the WNT pathway and ER stress regulates changes in metabolic activities of cancer cells suggesting these signaling pathways represent critical nodes in the regulation of central metabolism in tumors. 3. Results Findings suggest that the molecular cross-talks between hypoxic ER stress, Wnt/βcatenin signaling, may represent an important mechanism that enables some tumor subtypes to survival and grow in hypoxic conditions. 4. Conclusions The present article disuses differential effects of the activation of the three arms of UPR, namely endoplasmic reticulum kinase (PERK), activation transcription factor -6 (ATF-6), and inositol –requiring enzyme (IRE-1) on cancer. This review also highlights regulators and downstream effectors of Wnt cascade and addresses the increasingly apparent crosstalk of Wnt with other tumorigenic signaling pathways.
format	article
author	Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram
author_facet	Morvarid Siri Seyed Vahid Hosseini Sanaz Dastghaib Pooneh Mokarram
author_sort	Morvarid Siri
title	Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
title_short	Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
title_full	Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
title_fullStr	Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
title_full_unstemmed	Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer
title_sort	crosstalk between er stress, unfolded protein response (upr) and wnt signaling pathway in cancer
publisher	Shiraz University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/528b21c058b244bf89ed4213525b77ec
work_keys_str_mv	AT morvaridsiri crosstalkbetweenerstressunfoldedproteinresponseuprandwntsignalingpathwayincancer AT seyedvahidhosseini crosstalkbetweenerstressunfoldedproteinresponseuprandwntsignalingpathwayincancer AT sanazdastghaib crosstalkbetweenerstressunfoldedproteinresponseuprandwntsignalingpathwayincancer AT poonehmokarram crosstalkbetweenerstressunfoldedproteinresponseuprandwntsignalingpathwayincancer
_version_	1718429777296097280

Crosstalk Between ER Stress, Unfolded Protein Response (UPR) and Wnt Signaling Pathway in Cancer

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