Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo

Objective: Dexamethasone and Hydrocortisone are two glucocorticoids widely used to alleviate moderate to acute inflammation. But due to their different pharmacokinetics, potential of these drugs in initiation of abnormalities is not equivalent with their pharmacologic activities. Their different pha...

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Autores principales:	SN Ostad, M Abdollahi, M Akbari, H Marzban, N Babolmorad
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2000
Materias:	dexamethasone hydrocortisone teratogenic chick embryo toxicity Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/528d226c09504557b546a57b46d8b736
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id	oai:doaj.org-article:528d226c09504557b546a57b46d8b736
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spelling	oai:doaj.org-article:528d226c09504557b546a57b46d8b7362021-11-10T09:22:13ZComparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo1561-41072251-7170https://doaj.org/article/528d226c09504557b546a57b46d8b7362000-07-01T00:00:00Zhttp://jbums.org/article-1-2898-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Objective: Dexamethasone and Hydrocortisone are two glucocorticoids widely used to alleviate moderate to acute inflammation. But due to their different pharmacokinetics, potential of these drugs in initiation of abnormalities is not equivalent with their pharmacologic activities. Their different pharmacokinetics of absorption, distribution and metabolism result in production of different teratogenic effects on the embryo that may not be parallel to pharmacological potencies. Methods: After an incubation of 20 days, we removed the chick embryos from the eggs and studied the effects of drugs in development of abnormalities like embryonic toxicity. Findings: Results of this investigation showed that dexamethasone and hydrocortisone induce remarkable malformation in the doses of 410-4 mg and 210-1 mg respectively. Conclusion: This study showed that in the same dose dexamethasone is 500 times more potent than hydrocortisone in term of teratogenicity.SN OstadM AbdollahiM AkbariH MarzbanN BabolmoradBabol University of Medical Sciencesarticledexamethasonehydrocortisoneteratogenicchick embryotoxicityMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 2, Iss 3, Pp 12-16 (2000)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	dexamethasone hydrocortisone teratogenic chick embryo toxicity Medicine R Medicine (General) R5-920
spellingShingle	dexamethasone hydrocortisone teratogenic chick embryo toxicity Medicine R Medicine (General) R5-920 SN Ostad M Abdollahi M Akbari H Marzban N Babolmorad Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
description	Objective: Dexamethasone and Hydrocortisone are two glucocorticoids widely used to alleviate moderate to acute inflammation. But due to their different pharmacokinetics, potential of these drugs in initiation of abnormalities is not equivalent with their pharmacologic activities. Their different pharmacokinetics of absorption, distribution and metabolism result in production of different teratogenic effects on the embryo that may not be parallel to pharmacological potencies. Methods: After an incubation of 20 days, we removed the chick embryos from the eggs and studied the effects of drugs in development of abnormalities like embryonic toxicity. Findings: Results of this investigation showed that dexamethasone and hydrocortisone induce remarkable malformation in the doses of 410-4 mg and 210-1 mg respectively. Conclusion: This study showed that in the same dose dexamethasone is 500 times more potent than hydrocortisone in term of teratogenicity.
format	article
author	SN Ostad M Abdollahi M Akbari H Marzban N Babolmorad
author_facet	SN Ostad M Abdollahi M Akbari H Marzban N Babolmorad
author_sort	SN Ostad
title	Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
title_short	Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
title_full	Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
title_fullStr	Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
title_full_unstemmed	Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo
title_sort	comparison of dexamethasone and hydrocortisone teratogenic effect on chick embryo
publisher	Babol University of Medical Sciences
publishDate	2000
url	https://doaj.org/article/528d226c09504557b546a57b46d8b736
work_keys_str_mv	AT snostad comparisonofdexamethasoneandhydrocortisoneteratogeniceffectonchickembryo AT mabdollahi comparisonofdexamethasoneandhydrocortisoneteratogeniceffectonchickembryo AT makbari comparisonofdexamethasoneandhydrocortisoneteratogeniceffectonchickembryo AT hmarzban comparisonofdexamethasoneandhydrocortisoneteratogeniceffectonchickembryo AT nbabolmorad comparisonofdexamethasoneandhydrocortisoneteratogeniceffectonchickembryo
_version_	1718440101353095168

Comparison of Dexamethasone and Hydrocortisone teratogenic effect on chick embryo

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